Hierarchical error representation in medial prefrontal cortex

NeuroImage
Noah Zarr, Joshua W Brown

Abstract

The medial prefrontal cortex (mPFC) is reliably activated by both performance and prediction errors. Error signals have typically been treated as a scalar, and it is unknown to what extent multiple error signals may co-exist within mPFC. Previous studies have shown that lateral frontal cortex (LFC) is arranged in a hierarchy of abstraction, such that more abstract concepts and rules are represented in more anterior cortical regions. Given the close interaction between lateral and medial prefrontal cortex, we explored the hypothesis that mPFC would be organized along a similar rostro-caudal gradient of abstraction, such that more abstract prediction errors are represented further anterior and more concrete errors further posterior. We show that multiple prediction error signals can be found in mPFC, and furthermore, these are arranged in a rostro-caudal gradient of abstraction which parallels that found in LFC. We used a task that requires a three-level hierarchy of rules to be followed, in which the rules changed without warning at each level of the hierarchy. Task feedback indicated which level of the rule hierarchy changed and led to corresponding prediction error signals in mPFC. Moreover, each identified region of mPFC was ...Continue Reading

References

Aug 15, 1989·The Journal of Comparative Neurology·H Barbas, D N Pandya
Mar 25, 2000·Psychophysiology·K A KiehlJ B Hopfinger
Aug 8, 2001·Psychological Review·M M BotvinickJ D Cohen
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·George BushBruce R Rosen
Apr 27, 2002·Journal of Neurophysiology·M F S RushworthP K Sipila
Aug 17, 2002·Cerebral Cortex·Marcel Brass, D Yves von Cramon
Jun 20, 2003·NeuroImage·R DeichmannR Turner
Nov 15, 2003·Science·Etienne KoechlinFrédérique Kouneiher
Feb 14, 2004·Science·John G KernsCameron S Carter
Oct 16, 2004·Science·K Richard RidderinkhofSander Nieuwenhuis
Oct 21, 2004·Nature Neuroscience·Mark E WaltonMatthew F S Rushworth
Jun 2, 2005·Trends in Cognitive Sciences·Marcel BrassD Yves von Cramon
Dec 14, 2005·Neuroscience·O E Krigolson, C B Holroyd
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stefan DebenerAndreas K Engel
Apr 22, 2006·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Joaquín M Fuster
Jun 8, 2007·NeuroImage·Michael W Cole, Walter Schneider
Jul 3, 2007·NeuroImage·Daniel S MarguliesMichael P Milham
Sep 26, 2007·Journal of Cognitive Neuroscience·David Badre, Mark D'Esposito
Apr 19, 2008·Trends in Cognitive Sciences·Matthew M Botvinick
Jul 17, 2008·Experimental Brain Research·Olav E KrigolsonMathew Heath
Jun 9, 2009·Nature Neuroscience·Frédérique KouneiherEtienne Koechlin
Jun 10, 2009·Brain Research·Kalina ChristoffBurkhard Mädler
Aug 13, 2009·Nature Reviews. Neuroscience·David Badre, Mark D'Esposito
Oct 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vinod VenkatramanScott A Huettel
Mar 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ryan K JessupJoshua W Brown
Jun 1, 2000·Cognitive Neuropsychology·R Cooper, T Shallice
Apr 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adrienne A TarenScott A Huettel
Sep 20, 2011·Nature Neuroscience·William H Alexander, Joshua W Brown
Nov 16, 2011·Behavior Research Methods·Sebastiaan MathôtJan Theeuwes
Jun 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jan R WesselMarkus Ullsperger
Aug 31, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicola K FerdinandWilliam J Gehring
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carlos DiukYael Niv

❮ Previous
Next ❯

Citations

Jul 9, 2016·Attention, Perception & Psychophysics·Benjamin J Tamber-Rosenau, René Marois
Aug 27, 2016·Scientific Reports·Bihua CaoFuhong Li
May 27, 2017·Cognitive, Affective & Behavioral Neuroscience·G R WylieE Dobryakova
Jun 18, 2017·Psychophysiology·Francisco L ColinoOlave E Krigolson
Nov 14, 2017·Topics in Cognitive Science·William H Alexander, Joshua W Brown
Sep 22, 2018·Journal of Cognitive Neuroscience·José J F Ribas-FernandesMatthew M Botvinick
Mar 3, 2018·Scientific Reports·William H Alexander, Joshua W Brown
Feb 18, 2017·Nature Reviews. Neuroscience·Laurence T Hunt, Benjamin Y Hayden
Nov 16, 2016·Brain and Behavior·Bihua CaoHong Li
May 18, 2019·Science·Morteza Sarafyazd, Mehrdad Jazayeri
Dec 13, 2017·Trends in Cognitive Sciences·David Badre, Derek Evan Nee
Aug 29, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anne G E Collins, Amitai Shenhav
Oct 31, 2021·The European Journal of Neuroscience·Matias BaltazarLaurence Conty

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.