Hierarchical genomic analysis of carried and invasive serogroup A Neisseria meningitidis during the 2011 epidemic in Chad

BMC Genomics
Kanny DialloMartin C J Maiden

Abstract

Serogroup A Neisseria meningitidis (NmA) was the cause of the 2011 meningitis epidemics in Chad. This bacterium, often carried asymptomatically, is considered to be an "accidental pathogen"; however, the transition from carriage to disease phenotype remains poorly understood. This study examined the role genetic diversity might play in this transition by comparing genomes from geographically and temporally matched invasive and carried NmA isolates. All 23 NmA isolates belonged to the ST-5 clonal complex (cc5). Ribosomal MLST comparison with other publically available NmA:cc5 showed that isolates were closely related, although those from Chad formed two distinct branches and did not cluster with other NmA, based on their MLST profile, geographical and temporal location. Whole genome MLST (wgMLST) comparison identified 242 variable genes among all Chadian isolates and clustered them into three distinct phylogenetic groups (Clusters 1, 2, and 3): no systematic clustering by disease or carriage source was observed. There was a significant difference (p = 0.0070) between the mean age of the individuals from which isolates from Cluster 1 and Cluster 2 were obtained, irrespective of whether the person was a case or a carrier. Whole ge...Continue Reading

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Dec 7, 2017·Human Vaccines & Immunotherapeutics·Mustapha M Mustapha, Lee H Harrison
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Jan 31, 2019·Frontiers in Immunology·Martin Christopher James Maiden

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Datasets Mentioned

BETA
WUE2594
FR774048

Methods Mentioned

BETA
glycosylation
MDA

Clinical Trials Mentioned

NCT01119482

Software Mentioned

MEGA6
PubMLST
Artemis Comparison Tool
MAUVE
Genome Comparator
SplitsTree
Spades
MLST
Neighbor
wgMLST

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