Hierarchical Hydrogel Composite Interfaces with Robust Mechanical Properties for Biomedical Applications

Advanced Materials
Yuting ZhuDong Han

Abstract

Cells sense and respond to a wide range of external signals, including chemical signals, topography, and interface mechanics, via interactions with the extracellular matrix (ECM), triggering the regulation of behavior and function. The ECM can be considered a hierarchical multiphase porous matrix with various components. Highly porous hydrogel-based biomaterials can mimic the critical ECM properties, to provide mechanical support for tissues and to regulate cellular behaviors, such as adhesion, proliferation, and differentiation. Herein, based on micro/nanoscale-topography-coupled mechanical action, recent advances in the fabrication and application of hydrogel composites with tunable mechanical properties and topography in biomedicine are summarized. In particular, recent findings showing that hydrogels with specifically designed structures not only influence a range of cellular processes and fit the needs of engineered tissues but also have pharmacological effects are emphasized.

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Citations

Sep 10, 2020·Advanced Healthcare Materials·Sung-Ho ShinJeyoung Park
Mar 27, 2020·Frontiers in Chemistry·Zhongyang LiuPeifu Tang
Jul 31, 2020·Micromachines·Muhammad Asri Abdul SisakMichiya Matsusaki
Apr 30, 2021·ACS Applied Materials & Interfaces·Beibei LiuHuanjun Li
Mar 18, 2020·ACS Applied Materials & Interfaces·Juliana S RibeiroMarco C Bottino
Aug 21, 2021·Journal of Zhejiang University. Science. B·Hongyi LiHua Li
Jan 14, 2022·Chemical Reviews·Yue ZhaoYanli Zhao
Dec 4, 2020·Biofabrication·Zeyang LiuChengzhi Hu

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