Hierarchical mesoporous zinc-imidazole dicarboxylic acid MOFs: Surfactant-directed synthesis, pH-responsive degradation, and drug delivery.

International Journal of Pharmaceutics
Mehdi AbediAli Mohammad Tamaddon

Abstract

The surfactant template-directed solvothermal method was applied in the synthesis of hierarchical mesoporous zinc-imidazolate derivative metal-organic framework (mesoMOF), which was then utilized for active loading of cisplatin (cis-Pt). To fabricate mesoMOF, various amounts of the surfactant (cetyltrimethylammonium bromide: 0.1-0.3 g) and linker (citric acid: 0.05-0.15 g) were added to the reaction mixture, which resulted in different particle sizes and morphologies. MesoMOF quality attributes such as Specific surface area (SSA), total porous volume, and Barrett-Joyner-Halenda (BJH) pore diameter were also determined. At the optimum reaction condition, mesoMOF with a high surface area (1859 m2/g), pore diameter (14.13 nm) and total pore volume (0.314 cm3/g) was attained. In the next step, cis-Pt was actively loaded in the mesoMOF with a high loading capacity (28% w/w), which was remarkably superior to the microporous MOF. Interestingly, in mildly acidic pH (5.5), mesoMOF underwent degradation, resulting in a rapid release of cis-Pt. Cell viability and apoptosis induction assays confirmed the superiority of the cis-Pt loaded mesoMOF over free drug in a resistant ovarian tumor cell line (A2780cp). Altogether, due to their tunabl...Continue Reading

References

Aug 10, 2006·Angewandte Chemie·Patricia HorcajadaGérard Férey
Aug 9, 2008·Journal of the American Chemical Society·William J RieterWenbin Lin
Aug 29, 2009·Chemical Reviews·Alice V Klein, Trevor W Hambley
Mar 17, 2010·Journal of the American Chemical Society·Yu-Shen Lin, Christy L Haynes
Apr 9, 2010·Indian Journal of Pharmaceutical Sciences·G Ahuja, K Pathak
Sep 3, 2010·Journal of Nucleic Acids·Alakananda Basu, Soumya Krishnamurthy
Jun 22, 2011·Journal of Colloid and Interface Science·Jixi ZhangHong-chen Gu
Oct 20, 2011·Chemical Society Reviews·Weimin XuanYong Cui
Dec 14, 2011·Journal of the American Chemical Society·Lin-Bing SunHong-Cai Zhou
Dec 16, 2011·Chemical Reviews·Patricia HorcajadaChristian Serre
Oct 12, 2013·Advanced Drug Delivery Reviews·Hardeep S OberoiTatiana K Bronich
Mar 19, 2014·Molecular Cancer Therapeutics·Juan M ArriagaMichele Bianchini
Jul 23, 2014·Nature Communications·Li PengGuanying Yang
Apr 1, 2015·Journal of Colloid and Interface Science·Shijie Liu
Jan 14, 2016·Chemical Society Reviews·Daniel SchneiderRustem Valiullin
May 26, 2017·Nature Communications·Shuai YuanHong-Cai Zhou
Apr 26, 2018·ACS Applied Materials & Interfaces·Bingqian LeiZhimin He
May 20, 2018·Pharmaceutical Research·Gabriela WyszogrodzkaPiotr Kulinowski
Jul 26, 2018·Chemical Communications : Chem Comm·Qiang WangRong Cao
Dec 14, 2018·Chemical Communications : Chem Comm·Liwen ZhangNiveen M Khashab
Dec 28, 2018·Drug Design, Development and Therapy·Muder Al HaydarShaobin Wang
Jan 27, 2019·Photodiagnosis and Photodynamic Therapy·Saeed TaghizadehElina Kaviani
Feb 23, 2019·Physical Chemistry Chemical Physics : PCCP·Christoph Buttersack
Apr 3, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Shi-Xin LinDavid J Young
Jul 19, 2019·Journal of the American Chemical Society·Li PengWendy L Queen
Jul 30, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Munther AlomariJ Francis Borgio
Nov 20, 2019·Journal of the American Chemical Society·Sanfeng HeTao Li
Feb 28, 2020·Asian Journal of Pharmaceutical Sciences·Xin ZhengSiling Wang
Feb 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·María C BerniniRandall Q Snurr
Aug 3, 2020·Drug Delivery and Translational Research·Vahid AlimardaniMohammad Ashfaq
Jan 10, 2021·Journal of Clinical Medicine·Vahid AlimardaniSamad Ahadian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis