Hierarchical Micro-/Nanostructures from Human Hair for Biomedical Applications

Advanced Materials
Di-Wei ZhengXian-Zheng Zhang

Abstract

With the prominent progress of biomedical engineering, materials with high biocompatibility and versatile functions are urgently needed. So far, hierarchical structures in nature have shed some light on the design of high performance materials both in concept and implementation. Inspired by these, the hierarchical micro-/nanostructures of human hair are explored and human hair is further broken into hierarchical microparticles (HMP) and hierarchical nanoparticles (HNP) with top-down procedures. Compared with commercialized carriers, such as liposomes or albumin nanoparticles, the obtained particles exhibit high hemocompatibility and negligible immunogenicity. Furthermore, these materials also display attentional abilities in the aspects of light absorption and free radical scavenging. It is found that HMP and HNP can prevent skin from UV-induced damage and relieve symptoms of cataract in vitro. Besides, both HMP and HNP show satisfactory photothermal conversion ability. By using microcomputed tomography and intravital fluorescence microscopy, it is found that warfarin-loaded HMP can rescue mice from vein thrombosis. In another aspect, HNP modified with tumor targeted aptamers exhibit dramatic antineoplastic effect, and suppress...Continue Reading

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Citations

Jun 22, 2018·Advanced Materials·Di-Wei ZhengXian-Zheng Zhang
Dec 1, 2018·Nanoscale·Jing-Jing HuXian-Zheng Zhang
Jan 7, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhaojie WangZhigang Chen
Nov 24, 2020·Chemical Society Reviews·Guo-Feng LuoXian-Zheng Zhang
Nov 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cuifu FangXiaolei Wang
Jun 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaowei LuanYujun Song
Jun 24, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chang DuRong Zhang
Dec 5, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Ruili LiuJiandong Ding

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