Hierarchical Microplates as Drug Depots with Controlled Geometry, Rigidity, and Therapeutic Efficacy

ACS Applied Materials & Interfaces
Martina Di FrancescoPaolo Decuzzi

Abstract

A variety of microparticles have been proposed for the sustained and localized delivery of drugs with the objective of increasing therapeutic indexes by circumventing filtering organs and biological barriers. Yet, the geometrical, mechanical, and therapeutic properties of such microparticles cannot be simultaneously and independently tailored during the fabrication process to optimize their performance. In this work, a top-down approach is employed to realize micron-sized polymeric particles, called microplates (μPLs), for the sustained release of therapeutic agents. μPLs are square hydrogel particles, with an edge length of 20 μm and a height of 5 μm, made out of poly(lactic- co-glycolic acid) (PLGA). During the synthesis process, the μPL Young's modulus can be varied from 0.6 to 5 MPa by changing the PLGA amounts from 1 to 7.5 mg, without affecting the μPL geometry while matching the properties of the surrounding tissue. Within the porous μPL matrix, different classes of therapeutic payloads can be incorporated including molecular agents, such as anti-inflammatory dexamethasone (DEX), and nanoparticles containing imaging and therapeutic molecules themselves, thus originating a truly hierarchical platform. As a proof of princi...Continue Reading

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Citations

Jul 16, 2019·Nanoscale Advances·Daniele Di MascoloMarco Francardi
Oct 13, 2020·Nanotechnology·Paolo DecuzziTwan Lammers
Apr 15, 2020·Acta Biomaterialia·Fei TanMohamed Al-Rubeai
Nov 10, 2021·ACS Applied Materials & Interfaces·Rosita PrimaveraPaolo Decuzzi
Jan 2, 2022·Drug Delivery and Translational Research·Elena BellottiPaolo Decuzzi

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