Hierarchical modeling of force generation in cardiac muscle.

Biomechanics and Modeling in Mechanobiology
François Kimmig, M Caruel

Abstract

Performing physiologically relevant simulations of the beating heart in clinical context requires to develop detailed models of the microscale force generation process. These models, however, may reveal difficult to implement in practice due to their high computational costs and complex calibration. We propose a hierarchy of three interconnected muscle contraction models-from the more refined to the more simplified-that are rigorously and systematically related to each other, offering a way to select, for a specific application, the model that yields a good trade-off between physiological fidelity, computational cost and calibration complexity. The three model families are compared to the same set of experimental data to systematically assess what physiological indicators can be reproduced or not and how these indicators constrain the model parameters. Finally, we discuss the applicability of these models for heart simulation.

References

Jan 1, 1975·Progress in Biophysics and Molecular Biology·T L Hill
Aug 1, 1992·The Journal of Physiology·P P de Tombe, H E ter Keurs
Oct 1, 1988·The Journal of Physiology·K A Edman
Sep 1, 1985·Journal of Molecular and Cellular Cardiology·D G Allen, J C Kentish
Dec 7, 1971·Biochemistry·R W Lymn, E W Taylor
Jan 1, 1974·Progress in Biophysics and Molecular Biology·T L Hill
Oct 22, 1971·Nature·A F Huxley, R M Simmons
Feb 1, 1980·Biophysical Journal·E EisenbergY Chen
Feb 1, 1981·The Journal of Physiology·L E FordR M Simmons
Sep 25, 1995·Physical Review Letters·F Jülicher, J Prost
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·T A Duke
Jun 3, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K C Holmes, M A Geeves
Jan 12, 2002·Circulation Research·John P KonhilasPieter P de Tombe
Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·David P DobeshPieter P de Tombe
Nov 16, 2002·The Journal of Physiology·Gabriella PiazzesiVincenzo Lombardi
Apr 16, 2003·Journal of Biomechanics·Pieter P de Tombe
Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Pál PacherCsaba Szabó
Aug 25, 2007·The Journal of Physiology·Pieter P de Tombe, G J M Stienen
Apr 19, 2008·Pflügers Archiv : European journal of physiology·Tomoyoshi KobayashiPieter P de Tombe
May 29, 2008·Annals of Biomedical Engineering·D A Smith, S M Mijailovich
Jul 22, 2008·Annals of Biomedical Engineering·D A SmithS M Mijailovich
Oct 20, 2009·Progress in Biophysics and Molecular Biology·C J BarclayN A Curtin
Oct 1, 2006·Reports on Progress in Physics·Massimo Reconditi
Jan 8, 2010·Journal of Molecular and Cellular Cardiology·Pieter P de TombeThomas C Irving
Sep 28, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·L Marcucci, L Truskinovsky
Jun 28, 2011·The European Physical Journal. E, Soft Matter·T GuérinJ-F Joanny
Jul 29, 2011·Biomechanics and Modeling in Mechanobiology·R ChabiniokD Chapelle
Dec 10, 2013·Biomechanics and Modeling in Mechanobiology·M CaruelD Chapelle
Mar 19, 2014·Archives of Biochemistry and Biophysics·Gabriella PiazzesiVincenzo Lombardi
Jun 14, 2013·Physical Review Letters·M CaruelL Truskinovsky
Apr 17, 2015·Comprehensive Physiology·C J Barclay
May 12, 2015·BioMed Research International·Alf MånssonGeorgios Tsiavaliaris
Dec 15, 2015·Journal of Molecular and Cellular Cardiology·Daria Amiad Pavlov, Amir Landesberg
Mar 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Marco CaremaniMarco Linari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Briefings in Bioinformatics
Mark N ReadPaul S Andrews
Internal Medicine Journal
R Briant
Medical Image Computing and Computer-assisted Intervention : MICCAI
Shelten G YuenRobert D Howe
© 2021 Meta ULC. All rights reserved