Hierarchical protein export mechanism of the bacterial flagellar type III protein export apparatus

FEMS Microbiology Letters
Tohru Minamino

Abstract

The bacterial flagellum is supramolecular motility machinery consisting of the basal body, the hook and the filament. Flagellar proteins are translocated across the cytoplasmic membrane via a type III protein export apparatus, diffuse down the central channel of the growing structure and assemble at the distal end. Flagellar assembly begins with the basal body, followed by the hook and finally the filament. The completion of hook assembly is the most important morphological checkpoint of the sequential flagellar assembly process. When the hook reaches its mature length of about 55 nm in Salmonella enterica, the type III protein export apparatus switches export specificity from proteins required for the structure and assembly of the hook to those responsible for filament assembly, thereby terminating hook assembly and initiating filament assembly. Three flagellar proteins, namely FliK, FlhB and FlhA, are responsible for this substrate specificity switching. Upon completion of the switching event, interactions among FlhA, the cytoplasmic ATPase complex and flagellar type III export chaperones establish the assembly order of the filament at the hook tip. Here, we describe our current understanding of a hierarchical protein export ...Continue Reading

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Citations

Jul 25, 2019·Biomolecules·Shuichi Nakamura, Tohru Minamino
Oct 4, 2018·Frontiers in Microbiology·Katie M FordPushkar P Lele
Jun 9, 2020·Frontiers in Microbiology·Wendy Wai-Ling LamShannon Wing-Ngor Au
Sep 12, 2018·FEMS Microbiology Letters·Jozef AnnéAnastassios Economou
Nov 10, 2020·Computational and Structural Biotechnology Journal·Naoya TeraharaTohru Minamino
Feb 3, 2021·Journal of Microbiology and Biotechnology·Sang-Hyeok ChoSuhyung Cho
Jun 2, 2021·Communications Biology·Yumi InoueTohru Minamino

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