Hierarchical Tumor Microenvironment-Responsive Nanomedicine for Programmed Delivery of Chemotherapeutics

Advanced Materials
Sheng WangXiaoyuan Chen

Abstract

Nanomedicines have been demonstrated to have passive or active tumor targeting behaviors, which are promising for cancer chemotherapy. However, most nanomedicines still suffer from a suboptimal targeting effect and drug leakage, resulting in unsatisfactory treatment outcome. Herein, a hierarchical responsive nanomedicine (HRNM) is developed for programmed delivery of chemotherapeutics. The HRNMs are prepared via the self-assembly of cyclic Arg-Gly-Asp (RGD) peptide conjugated triblock copolymer, poly(2-(hexamethyleneimino)ethyl methacrylate)-poly(oligo-(ethylene glycol) monomethyl ether methacrylate)-poly[reduction-responsive camptothecin] (PC7A-POEG-PssCPT). In blood circulation, the RGD peptides are shielded by the POEG coating; therefore, the nanosized HRNMs can achieve effective tumor accumulation through passive targeting. Once the HRNMs reach a tumor site, due to the hydrophobic-tohydrophilic conversion of PC7A chains induced by the acidic tumor microenvironment, the RGD peptides will be exposed for enhanced tumor retention and cellular internalization. Moreover, in response to the glutathione inside cells, active CPT drugs will be released rapidly for chemotherapy. The in vitro and in vivo results confirm effective tumor...Continue Reading

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Citations

Nov 21, 2019·Macromolecular Bioscience·Yue WangZhaohui Tang
Nov 23, 2019·Macromolecular Rapid Communications·Zhengyu DengShiyong Liu
Jan 1, 2020·Chembiochem : a European Journal of Chemical Biology·Xing Qin, Yongsheng Li
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May 14, 2020·Angewandte Chemie·Yue Wang, Chengzhong Yu
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Aug 11, 2020·Frontiers in Chemistry·Wenbo ZhangChenxuan Wang
Oct 20, 2020·Advanced Healthcare Materials·Hyeongmok ParkWon Jong Kim
Mar 16, 2021·Matter·Xu ZhangXiaoyuan Chen
Apr 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Le WangXingyu Jiang
May 1, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qi SuWeiwei Wang
May 15, 2021·Advanced Materials·Sheng WangXiaoyuan Chen
May 11, 2021·Biomedical Materials·Qingmei SunJianzhong Du
Dec 24, 2019·ACS Nano·Zijian ZhouXiaoyuan Chen
Mar 6, 2019·ACS Nano·Weijing YangXiaoyuan Chen
Jan 24, 2019·ACS Applied Materials & Interfaces·Li WangShuyun Zhou
Aug 24, 2021·Advanced Functional Materials·Binglin SuiPeisheng Xu
Oct 12, 2021·Journal of the American Chemical Society·Maksymilian Marek ZegotaTanja Weil

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