Hierarchically mesoporous-macroporous bioactive glasses scaffolds for bone tissue regeneration

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Hui-suk YunJung-wook Shin

Abstract

Hierarchically 2D/3D mesoporous-macroporous bioactive glasses (MMBG) with good molding capabilities and compressive modulus were synthesized by sol-gel method and evaporation-induced self-assembly process in the presence of both nonionic triblock copolymers, EO(70)PO(20)EO(70) (P123) or EO(100)PO(65)EO(100) (F127), templates and methyl cellulose template. P123 or F127 acts as both a template, inducing the formation of mesopore, and an effective dispersant of MC, which produces macropores. In vitro bioactivity studies were carried out in simulated body fluid and showed superior bone-forming bioactivities of hierarchical MMBG. Human osteoblastlike cells, MG63, were seeded on MMBG and were determined using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5,-diphenyl-tetrazolium bromide] assay to confirm biocompatibilities of MMBG.

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Citations

Oct 30, 2009·Journal of the Royal Society, Interface·Viviana Mouriño, Aldo R Boccaccini
Jul 10, 2013·International Journal of Nanomedicine·Wenyi GuYin Xiao
Feb 9, 2016·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Mina D FahmyLobat Tayebi
Sep 11, 2012·Journal of Biomedical Materials Research. Part a·Thi-Hiep Nguyen, Byong-Taek Lee
Jun 11, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gurbinder KaurDaniel Homa
Apr 25, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Xiao WangXinquan Jiang
Feb 22, 2012·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·María Vallet-RegíMontserrat Colilla
Nov 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jianhua ZhangChangqing Zhang
Mar 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yufang ZhuStefan Kaskel

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