PMID: 11927290Apr 3, 2002Paper

HIF-1 and tumor progression: pathophysiology and therapeutics

Trends in Molecular Medicine
Gregg L Semenza

Abstract

Hypoxia-inducible factor 1 (HIF-1) controls oxygen delivery (via angiogenesis) and metabolic adaptation to hypoxia (via glycolysis). HIF-1 consists of a constitutively expressed HIF-1 beta subunit and an oxygen- and growth-factor-regulated HIF-1 alpha subunit. In xenografts, tumor growth and angiogenesis are correlated with HIF-1 expression. In human cancers, HIF-1 alpha is overexpressed as a result of intratumoral hypoxia and genetic alterations affecting key oncogenes and tumor suppressor genes. HIF-1 alpha overexpression in biopsies of brain, breast, cervical, esophageal, oropharyngeal and ovarian cancers is correlated with treatment failure and mortality. Increased HIF-1 activity promotes tumor progression, and inhibition of HIF-1 could represent a novel approach to cancer therapy.

References

Mar 31, 2000·Molecular Medicine Today·J M Brown
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·C H SutterG L Semenza
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·R K Bruick
Feb 22, 2001·Journal of the National Cancer Institute·M Höckel, P Vaupel
Feb 22, 2001·Journal of the National Cancer Institute·R BosE van der Wall
Apr 21, 2001·Molecular and Cellular Biology·T N SeagrovesR S Johnson
Aug 2, 2001·Journal of the National Cancer Institute·A CostaM G Daidone
Aug 23, 2001·Trends in Molecular Medicine·G L Semenza
Feb 2, 2002·Science·David LandoMurray L Whitelaw

❮ Previous
Next ❯

Citations

May 27, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Vadim V Sumbayev, Sally A Nicholas
Dec 21, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·L Eric HuangAdrian L Harris
Sep 25, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Vivek SharmaEllora Sen
Feb 22, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antonio SicaLuigi Varesio
Sep 3, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Richa TewariEllora Sen
Jul 15, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Michael ZimnyPatrick Reinartz
Aug 17, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Ashley M GrovesMohammed R Keshtgar
Mar 1, 2012·European Radiology·K A MilesUNKNOWN Experimental Cancer Medicine Centre Imaging Network Group
Mar 3, 2012·World Journal of Urology·Thomas K HamiltonD Robert Siemens
Oct 22, 2008·Archives of Gynecology and Obstetrics·Masaki MiyazawaR Yoshiyuki Osamura
Jul 11, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Carl M SheridanDavid Kent
Nov 7, 2008·Histochemistry and Cell Biology·Girieca Lorusso, Curzio Rüegg
Oct 26, 2005·Breast Cancer Research and Treatment·N V RajeshkumarAnil Gulati
Nov 12, 2010·Breast Cancer Research and Treatment·Paola MaroniMaria Alfonsina Desiderio
Apr 4, 2007·Cancer Metastasis Reviews·D LukashevM Sitkovsky
Apr 19, 2007·Cancer Metastasis Reviews·Peter Vaupel, Arnulf Mayer
Mar 27, 2007·Pharmaceutical Research·Renu M Stephen, Robert J Gillies
Jul 16, 2008·Journal of Biomedical Science·Chia-Yu ChuMin-Liang Kuo
Jan 16, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jing TaoChunyou Wang
Jan 15, 2003·Current Treatment Options in Oncology·Terry A DayRobert K Stuart
Apr 24, 2009·Archives of Pharmacal Research·Jae Yoon ChungKyeong Lee
Sep 17, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Miao-Zhen QiuRui-Hua Xu
May 7, 2004·Cancer Letters·Yang-Sook ChunJong-Wan Park
Jul 18, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Corey J LangerNick Thatcher
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Dirk Vordermark, J Martin Brown
Feb 27, 2004·Pediatric Neurology·Alberto LazarowskiAna Lía Taratuto
Dec 12, 2002·Trends in Endocrinology and Metabolism : TEM·Anna Bagnato, Francesca Spinella
Mar 5, 2003·Trends in Molecular Medicine·Marya F McCartyLee M Ellis
Oct 14, 2008·Journal of Medicinal Chemistry·Michael P HayWilliam A Denny
Feb 5, 2013·Acta Pharmacologica Sinica·Guomin ShenYaguang Xi
Dec 4, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J Ye
Feb 26, 2008·Nature Cell Biology·Muh-Hwa YangKou-Juey Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.