HIF-1, Metabolism, and Diabetes in the Embryonic and Adult Heart

Frontiers in Endocrinology
Radka Cerychova, Gabriela Pavlinkova

Abstract

The heart is able to metabolize any substrate, depending on its availability, to satisfy its energy requirements. Under normal physiological conditions, about 95% of ATP is produced by oxidative phosphorylation and the rest by glycolysis. Cardiac metabolism undergoes reprograming in response to a variety of physiological and pathophysiological conditions. Hypoxia-inducible factor 1 (HIF-1) mediates the metabolic adaptation to hypoxia and ischemia, including the transition from oxidative to glycolytic metabolism. During embryonic development, HIF-1 protects the embryo from intrauterine hypoxia, its deletion as well as its forced expression are embryonically lethal. A decrease in HIF-1 activity is crucial during perinatal remodeling when the heart switches from anaerobic to aerobic metabolism. In the adult heart, HIF-1 protects against hypoxia, although its deletion in cardiomyocytes affects heart function even under normoxic conditions. Diabetes impairs HIF-1 activation and thus, compromises HIF-1 mediated responses under oxygen-limited conditions. Compromised HIF-1 signaling may contribute to the teratogenicity of maternal diabetes and diabetic cardiomyopathy in adults. In this review, we discuss the function of HIF-1 in the he...Continue Reading

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Citations

May 2, 2019·Frontiers in Physiology·Agnieszka Polak-IwaniukAdrian Chabowski
Aug 28, 2020·Frontiers in Genetics·Matthew E PamenterTatum S Simonson
Jun 15, 2019·Proceedings of the National Academy of Sciences of the United States of America·Romana BohuslavovaGabriela Pavlinkova
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Jul 13, 2021·Chinese Journal of Natural Medicines·Chao YangYi-Tao Wang

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