HIF-1α up-regulation is associated with adverse clinicopathological and biological factors in neuroblastomas

Histopathology
Josiah V DungwaPramila Ramani

Abstract

To study the expression of hypoxia-inducible factor 1α (HIF-1α) in clinical neuroblastoma (NB) samples and its association with the clinicopathological features, biological features and survival of NB patients. Immunohistochemistry indicated that elevated HIF-1α expression was present in 30 of 90 (33%) NBs. This expression was correlated significantly and positively with higher clinical stage (P = 0.002), ≥18 months of age at presentation (P = 0.020), high-risk group (P = 0.005), unfavourable pathology (P = 0.002), MYCN amplification (P < 0.001), 1p deletion (P = 0.004) and 17q gain (P = 0.002). Enzyme-linked immunosorbent assays showed that total HIF-1α protein was significantly higher in NBs of patients with all examined adverse prognostic factors except for age. Univariate survival analysis revealed that higher-than-median HIF-1α total protein levels were associated significantly with a decrease in event-free survival (EFS) (P = 0.017), but not in overall survival (OS) (P = 0.12). HIF-1α immunoexpression by ≥10% of tumour cells was associated significantly with decreased OS and EFS (P = 0.002 and P = 0.004, respectively), but not in multivariate analysis after adjusting for the high-risk group (P = 0.16 and P = 0.19, respect...Continue Reading

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Citations

Aug 26, 2014·PloS One·Vasantha Kumar BhaskaraSanjeeva Mohanam
Oct 8, 2014·Molecular Neurobiology·Wen-Chin WengHsinyu Lee
Mar 26, 2015·PloS One·Deepak P EdwardKhaled K Abu Amero
Oct 17, 2017·Cell and Tissue Research·Sven Påhlman, Sofie Mohlin
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Apr 18, 2019·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Malgorzata Anna KrawczykEwa Bien

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