HIF1α allows monocytes to take a breather during sepsis

Immunity
Derek W Gilroy, Simon Yona

Abstract

How the immune system is negatively affected by sepsis is not fully understood. In this issue of Immunity, Shalova et al. (2015) show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties.

References

Jul 16, 2010·Blood·Loems Ziegler-HeitbrockManfred B Lutz

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Citations

Oct 29, 2015·Journal of Immunology Research·Henrique Borges da SilvaMaria Regina D'Império Lima
Feb 12, 2017·Pflügers Archiv : European journal of physiology·Anna C Aschenbrenner, Joachim L Schultze

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