Oct 3, 2014

HiFive: a tool suite for easy and efficient HiC and 5C data analysis

BioRxiv : the Preprint Server for Biology
Michael EG SauriaJames Taylor

Abstract

The chromatin interaction assays 5C and HiC have advanced our understanding of genomic spatial organization but analysis approaches for these data are limited by usability and flexibility. The HiFive tool suite provides efficient data handling and a variety of normalization approaches for easy, fast analysis and method comparison. Integration of MPI-based parallelization allows scalability and rapid processing time. In addition to single-command analysis of an entire experiment from mapped reads to interaction values, HiFive has been integrated into the open-source, web-based platform Galaxy to connect users with computational resources and a graphical interface. HiFive is open-source software available from http://taylorlab.org/software/hifive/ and https://github.com/bxlab/hifive.

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Mentioned in this Paper

Computer Software
Genome
Myocardial Perfusion Imaging
Genomics
TGFB1I1 gene
Chromatin Location
Analysis
Assay
Chromatin
Research Study

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