High α-tocopherol dosing increases lipid metabolism by changing redox state in damaged rat gastric mucosa and liver after ethanol treatment

Clinical Science
Marisela Olguín-MartínezRolando Hernández-Muñoz

Abstract

Regeneration of ethanol-injured rat gastric mucosa must undergo changes in major metabolic pathways to achieve DNA replication and cell proliferation. These events are highly dependent on glucose utilization and inhibited by vitamin E (VE) (α-tocopherol) administration. Therefore, the present study aimed at assessing lipid metabolism in the gastric mucosa and ethanol-induced gastric damage and the effect of α-tocopherol administration. For this, rates of fatty acid β-oxidation and lipogenesis were tested in gastric mucosa samples. Through histological analysis, we found loss of the mucosa's superficial epithelium, which became gradually normalized during the recovery period. Proliferation of gastric mucosa occurred with augmented formation of β-oxidation by-products, diminished synthesis of triacylglycerols (TGs), as well as of phospholipids, and a reduced cytoplasmic NAD/NADH ratio, whereas the mitochondrial redox NAD/NADH ratio was much less affected. In addition, α-tocopherol increased palmitic acid utilization in the gastric mucosa, which was accompanied by the induction of 'mirror image' effects on the cell redox state, reflected in an inhibited cell gastric mucosa proliferation by the vitamin administration. In conclusion...Continue Reading

References

Jun 8, 1989·Biochimica Et Biophysica Acta·M LocherK F Sewing
Jan 1, 1972·The American Journal of Physiology·T J Sernka, J B Harris
Sep 1, 1972·The American Journal of Physiology·J KatzJ B Harris
Aug 15, 1984·Biochemical Pharmacology·R Hernández-MuñozV Chagoya de Sánchez
Jan 12, 1982·Biochimica Et Biophysica Acta·S J HerseyA Owirodu
Aug 23, 1996·The Journal of Biological Chemistry·S Jackowski
Nov 1, 1996·Digestive Diseases and Sciences·R Hernández-Muñoz, F Montiel-Ruíz
Jan 8, 1998·Biochimica Et Biophysica Acta·M C Fernández-ToméN B Sterin-Speziale
Jan 24, 1998·Archives of Biochemistry and Biophysics·M Díaz-MuñozR Hernández-Muñoz
Aug 19, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·R Hernández-MuñozO Vázquez-Martínez
Jul 10, 2001·American Journal of Physiology. Cell Physiology·A M ChengS J Hagen
Jul 11, 2001·Biochemical and Biophysical Research Communications·A FischerG Rimbach
Mar 11, 2003·Experimental Biology and Medicine·Ileana Hernández-RincónRolando Hernández-Muñoz
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rolando Hernández-MuñozMyrna A R Dent
Nov 15, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Cristina Trejo-SolísRolando Hernández-Muñoz
Aug 21, 2004·Biological Chemistry·Angelo AzziJean-Marc Zingg
Nov 26, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takatoshi MuraseIchiro Tokimitsu
Jun 28, 2005·Atherosclerosis·Nesrin Kartal OzerAngelo Azzi
Jul 26, 2006·World Journal of Gastroenterology : WJG·Ricardo Vázquez-RamírezRolando Hernández-Muñoz
Sep 12, 2006·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Mehrafarin FesharakiNooshin Amirpoor
Oct 4, 2006·Free Radical Biology & Medicine·Marisela Olguín-MartínezRolando Hernández-Muñoz
Apr 19, 2007·Annual Review of Nutrition·Maret G Traber
Feb 2, 2008·Biochimica Et Biophysica Acta·Maik HüttemannJeffrey W Doan
Oct 13, 2009·Free Radical Biology & Medicine·Debbie J MustacichMaret G Traber
Oct 20, 2010·Journal of Biochemical and Molecular Toxicology·Rodrigo Polimeni ConstantinNair Seiko Yamamoto
Dec 8, 2011·Antioxidants & Redox Signaling·Diane E Handy, Joseph Loscalzo
May 15, 2013·Free Radical Biology & Medicine·Xiaodong WangArthur I Cederbaum
May 22, 2017·Biochemical Pharmacology·Daniel Villalobos-García, Rolando Hernández-Muñoz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.