High- versus low-dose leucovorin in the modified FOLFOX6 regimen for first-line treatment of metastatic colorectal cancer

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Jana ReynoldsLucas Wong

Abstract

Background In response to the national leucovorin shortage in 2008, our institution adjusted the modified FOLFOX6 (leucovorin, fluorouracil, and oxaliplatin) protocol to utilize a lower dose of leucovorin (20 mg/m(2)). This adjustment was based on prospective studies suggesting that lower doses of leucovorin may be equally effective in other fluorouracil containing regimens. This retrospective study evaluates outcomes in metastatic colorectal cancer (mCRC) patients treated with low- (20 mg/m(2)) vs. high-dose (400 mg/m(2)) leucovorin in the FOLFOX6 regimen for mCRC. Methods This retrospective analysis included consecutive mCRC patients from 2004 to 2011 if they received at least one cycle of modified FOLFOX6 as first line therapy. Patients who received an initial leucovorin dose other than 20 mg/m(2) or 400 mg/m(2) on their first cycle were excluded. Patient characteristics included demographics, metastatic site at initial diagnosis, and treatment history including chemotherapy and surgery. Primary outcome was date of death or last contact. Cox proportional hazards regression analysis and Kaplan-Meier survival curves were utilized to evaluate the effect of leucovorin dose on overall survival. Log-rank tests were used to compare...Continue Reading

References

Nov 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A PoonJ A Mailliard
Oct 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N PetrelliF M Muggia
Jun 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C G LeichmanA Mangalik
Sep 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P ThirionUNKNOWN Meta-Analysis Group in Cancer
Apr 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard B SaltzJim Cassidy
Feb 22, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·James M HoffmanGlen T Schumock
Mar 19, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

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Citations

Jul 2, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C-Y HsuK-W Tam
Sep 22, 2017·International Journal of Colorectal Disease·N M VerweijM E Hamaker

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