PMID: 3773353Mar 1, 1986Paper

High 1,25-dihydroxyvitamin D and low 25-hydroxyvitamin D concentrations in plasma in patients receiving antiepileptic drugs

The Japanese Journal of Psychiatry and Neurology
K Maeda, H Ikeda

Abstract

Plasma 25-hydroxyvitamin D (25-OH D), 1,25-dihydroxyvitamin D (1,25-(OH)2 D) and parathyroid hormone (PTH) concentrations were determined in 30 outpatients receiving various antiepileptic drugs (AED). None of the patients exhibited high plasma PTH levels. The plasma 1,25-(OH)2 D levels were normal or high, although in a third of the patients the 25-OH D levels were reduced. There was a correlation between the 25-OH D and serum calcium levels. These findings suggest that the low plasma concentrations of 25-OH D, not 1,25-(OH)2 D, might play an important part in the occurrence of AED-induced disturbances of bone metabolism.

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Citations

May 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M J VälimäkiR Tunninen
Jun 1, 1989·Acta Neurologica Scandinavica·D HartwellP Rødbro
Mar 17, 2004·The Proceedings of the Nutrition Society·Vanessa J PoustieRosalind L Smyth
Jan 12, 2013·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kim RobienJill M Hamilton-Reeves

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