High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3

Acta Radiologica
Isadora Pontes CavalcanteMaria Candida Barisson Villares Fragoso

Abstract

Primary macronodular adrenal hyperplasia (PMAH) is a rare cause of Cushing's syndrome, characterized by functioning adrenal macronodules and variable cortisol production. Recently, we demonstrated a high 18F-FDG uptake in PMAH, an unexpected finding for a benign disorder. To investigate whether there is a correlation between 18F-FDG high uptake and the expression levels of the glycolytic pathway components GLUT1, HK1, HK2, and HK3 in PMAH. We selected 12 patients undergoing surgery for PMAH who had preoperatively undergone 18F-FDG PET/CT. mRNA and protein expression of the selected genes were evaluated in the adrenal nodules from patients who underwent surgery through quantitative RT-PCR and by immunohistochemistry, respectively. SUVmax in PMAH was in the range of 3.3-8.9 and the adrenal size was in the range of 3.5-15 cm. A strong correlation between 18F-FDG uptake and largest adrenal diameter was observed in patients with PMAH. However, no correlation between 18F-FDG uptake and GLUT1, HK1, HK2, HK3 mRNA, and protein expression was observed. High 18F-FDG uptake is observed in the majority of PMAH cases. However, 18F-FDG uptake in PMAH is independent of the expression levels of GLUT1, HK1, HK2, and HK3. Further investigation is...Continue Reading

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Citations

Jul 30, 2020·Journal of the Endocrine Society·Fabio Yoshiaki TannoMaria Candida Barisson Villares Fragoso
Mar 3, 2019·Journal of Cancer Research and Clinical Oncology·Min YuZhixiang Jian
Mar 17, 2021·Nuclear Medicine and Biology·Ai-Mei LiMing Shi

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Methods Mentioned

BETA
PMAH
Assay
PCR

Software Mentioned

Bioestat

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