High absolute lymphocyte counts are associated with longer overall survival in patients with metastatic breast cancer treated with eribulin-but not with treatment of physician's choice-in the EMBRACE study

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Yasuo MiyoshiJavier Cortes

Abstract

Eribulin, a nontaxane synthetic inhibitor of microtubule dynamics, is widely used to manage locally advanced or metastatic breast cancer (MBC). Eribulin has demonstrated immunomodulatory activity on the tumour microenvironment. Baseline neutrophil-to-lymphocyte ratio (NLR), a marker of immune status, may predict progression-free survival in eribulin treatment. This post hoc analysis assessed predictors for overall survival (OS). The phase 3 open-label study (EMBRACE) of eribulin versus treatment of physician's choice (TPC) in patients with MBC provided source data. Baseline absolute lymphocyte counts (ALCs) and NLR were evaluable in 751 and 713 patients, respectively. Eribulin prolonged OS versus TPC in patients with baseline ALC ≥ 1500/µl (hazard ratio [HR] 0.586; 95% confidence interval [CI] 0.437-0.784; P < 0.001). There was no significant difference by treatment for ALC < 1500/µl (HR 1.002; 95% CI 0.800-1.253; P = 0.989). Univariate and multivariate analyses were performed and identified baseline ALC as a potential predictor of OS in eribulin-treated patients. Interaction analysis of OS supported 1500/µl as a potentially differential cutoff value. NLR at a cutoff value of 3 was associated with prolonged OS (eribulin group)....Continue Reading

References

Mar 23, 2006·Annual Review of Immunology·Ming O LiRichard A Flavell
Mar 8, 2011·Lancet·Javier CortesUNKNOWN EMBRACE (Eisai Metastatic Breast Cancer Study Assessing Physician's Choice Versus E7389) investigators
Jan 25, 2012·Gene Expression·Molly A TaylorWilliam P Schiemann
Apr 30, 2014·The Journal of Experimental Medicine·Muhammad Zaeem NomanSalem Chouaib
Jan 7, 2017·Breast Cancer Research : BCR·Josee-Lyne EthierEitan Amir

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Citations

Mar 5, 2021·Breast Cancer : Targets and Therapy·Peng Yuan, Binghe Xu
Mar 8, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Masato TakahashiJunji Tsurutani
Apr 2, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·José M Pérez-GarcíaJavier Cortés

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Methods Mentioned

BETA
xenograft

Software Mentioned

SAS
EMBRACE

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