PMID: 8971799Nov 22, 1996Paper

High affinity binding for pramipexole, a dopamine D3 receptor ligand, in rat striatum

Neuroscience Letters
M F PierceyM Camacho-Ochoa

Abstract

Quantitative autoradiography of rat brain slices was carried out with eight concentrations of [3H]pramipexole, a dopamine D3 receptor-preferring ligand. Saturation analysis revealed high affinity pramipexole binding (Kd = 0.2-0.4 nM) in the islets of Calleja, nucleus accumbens, olfactory tubercle, and anterior caudate. Since these affinities resemble pramipexole's affinity for the high affinity state of the rat dopamine D3, but not D2 receptors, it is possible that dopamine D3 receptors have greater presence in caudate than has heretofore been appreciated.

Citations

Oct 16, 2015·CNS Neuroscience & Therapeutics·Barbara KosmowskaKrystyna Ossowska
Feb 22, 2012·Neuroscience and Biobehavioral Reviews·Kanwar VirdeeJeffrey W Dalley
Jun 29, 2004·Biological Psychiatry·Carlos A ZarateHusseini K Manji
Dec 25, 2012·Journal of Affective Disorders·Bernardo Dell'ossoTerence A Ketter
Jun 28, 2016·European Journal of Pharmacology·Sandro FenuGaetano Di Chiara
Sep 1, 1996·The Journal of Eukaryotic Microbiology·U GrossD J Ferguson

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