High affinity binding site-mediated prevention of chemical absorption across the gastrointestinal tract

Toxicology Letters
M V RasmussenL K Silbart

Abstract

Preventing mucosal absorption of low-molecular weight compounds such as carcinogens, toxins and drugs could help prevent many diseases. To characterize the effects of dose and timing on high-affinity binding site mediated sequestration of specific chemical ligands in the gastrointestinal tract, avidin was perorally-administered to mice either prior to or mixed with 3H-biotin. Avidin enhanced fecal 3H-biotin excretion in a dose-dependent manner, consistent with the accepted mechanism of egg white-induced biotin deficiency syndrome. Avidin administration up to 4 h before 3H-biotin administration also enhanced fecal 3H-biotin excretion. Activated charcoal (AC) reduced 3H-biotin absorption when mixed with 3H-biotin before ingestion, but was ineffective when ingested prior to 3H-biotin. These studies suggest that ingestion of high-affinity protein binding sites can establish an absorptive barrier at the gastrointestinal mucosa to prevent the uptake of unwanted low molecular-weight chemicals.

References

Nov 1, 1990·The British Journal of Nutrition·J ScholtissekM Frigg
Nov 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M Hsu, L Raine
Feb 19, 1996·Mutation Research·O AlabasterN Shivapurkar
Apr 7, 1998·Nature Biotechnology·T ArakawaW H Langridge
Nov 10, 1998·Journal of Immunotherapy·M V Rasmussen, L K Silbart

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Citations

Jun 10, 2008·Bioscience, Biotechnology, and Biochemistry·Ryosuke MatsuokaKatsumi Imaizumi
Jan 25, 2005·The Journal of Pharmacology and Experimental Therapeutics·Stefan S De BuckClaude P Muller

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