High affinity heparin detection by multivalent supramolecular polymers through aggregation induced emission.

Chemical Communications : Chem Comm
Shubhra Kanti BhaumikSupratim Banerjee

Abstract

Amphiphilic di-cationic cyanostilbene derivatives with aggregation induced emission (AIE) features formed luminescent supramolecular polymers in aqueous media. They bind bio-polyanion heparin, a known anticoagulant, in a multivalent fashion through the formation of co-assemblies with highly enhanced greenish-yellow emission. Heparin detection in nanomolar concentrations in buffer and in medically relevant concentrations in human serum and plasma was achieved.

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Citations

Jul 28, 2021·Analytical Methods : Advancing Methods and Applications·Zhixiao HeHongyuan Yan
Aug 5, 2021·Chemical Society Reviews·Weiwei HanJonathan L Sessler

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Methods Mentioned

BETA
transmission
scanning electron microscopy
dynamic light scattering

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