PMID: 6162454Aug 15, 1980Paper

High affinity of alpha-foetoprotein for arachidonate and other fatty acids

The Biochemical Journal
R N CarlssonE Ruoslahti

Abstract

Fatty acid analysis of purified bovine alpha-foetoprotein showed it to contain 2.7 mol of fatty acid/mol of alpha-foetoprotein. Purified alpha-foetoprotein focused at isoelectric point 4.8. Removal of bound ligands from alpha-foetoprotein by charcoal treatment changed its isoelectric point to 5.2. This change could be reversed by addition of exogenous fatty acids to the defatted alpha-foetoprotein. Albumin isolated from the same foetal calf serum source as alpha-foetoprotein contained 1.4 mol of fatty acid/mol of protein. alpha-Foetoprotein and albumin contained comparable amounts of fatty acids with 14 to 18 carbon atoms, but alpha-foetoprotein contained 16 times as much of the long-chain polyunsaturated fatty acids as albumin. alpha-Foetoprotein was found to have slightly higher affinity for palmitate and linoleate and severalfold higher affinity for arachidonate than albumin. These findings suggest that alpha-foetoprotein may play a role in the foetal metabolism of the long-chain polyunsaturated fatty acids.

Citations

Jan 1, 1983·Annals of the New York Academy of Sciences·H F Deutsch
Jan 1, 1985·Journal of Cellular Biochemistry·M D PierschbacherE Ruoslahti
Jan 1, 1983·Annals of the New York Academy of Sciences·J UrielA Pineiro
Nov 11, 1999·Oncogene·B E Stronach, N Perrimon
Jul 29, 1983·Journal of Chromatography·G BirkenmeierG Kopperschläger
Apr 15, 1988·Biochimica Et Biophysica Acta·M CalvoA Piñeiro
Jan 1, 1991·Progress in Lipid Research·S M Innis
Jan 1, 1982·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·F LampreaveA Piñeiro
Jan 1, 1985·The International Journal of Biochemistry·J F Glatz, J H Veerkamp

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