PMID: 6158989Aug 1, 1980Paper

High affinity of lead for fetal haemoglobin

British Journal of Industrial Medicine
C N Ong, W R Lee

Abstract

In-vitro experiments using 203Pb were performed to identify lead-binding components in human haemoglobin. Sephadex A-50 ion-exchange chromatography of haemolysate showed that different types of haemoglobin had different affinities for lead. For the haemolysate from adults, lead was present in both Hb A (alpha 2 beta 2) and Hb A2 (alpha 2 delta 2), whereas, in the haemolysate from new-born infants, the haemoglobin of fetal origin, Hb F (alpha 2 gamma 2) showed a much greater affinity for 203Pb than the adult haemoglobin Hb A (alpha 2 beta 2), obtained from maternal blood. Analysis of the 203 Pb-labelled haemoglobin suggested that about 82% of 203Pb was in the globin polypeptide. Further analysis with carboxylmethyl (CM) cellulose chromatography indicated that the gamma globin of fetal origin had a higher affinity for 203Pb than the beta globin, whereas alpha globin appeared to be unimportant in lead binding. The results of the different affinities for lead of different Hb types are discussed with regard to the effect of lead upon haemoglobin synthesis.

References

Feb 22, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·N TaniguchiK Saito
Nov 1, 1972·British Journal of Haematology·A Goldberg
Jul 1, 1974·British Journal of Haematology·S K Piddington, J M White
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Jun 1, 1969·British Journal of Haematology·K H WinterhalterC A Finch
Feb 1, 1980·British Journal of Industrial Medicine·C N Ong, W R Lee
Feb 1, 1980·British Journal of Industrial Medicine·C N Ong, W R Lee
Apr 1, 1958·British Journal of Industrial Medicine·T W CLARKSON, J E KENCH

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Citations

Jan 1, 1988·European Journal of Pediatrics·G A DraschC Lochner
Oct 1, 1983·Archives of Toxicology·B R DanielssonA Lindgren
Jan 1, 1997·Biological Trace Element Research·Y GélinasJ P Schmit
Jun 1, 1988·The Science of the Total Environment·M R Moore
Dec 1, 1991·Toxicology Letters·A A OlkowskiD A Christensen
Dec 13, 1980·British Medical Journal·D Gloag
Mar 22, 2005·Occupational and Environmental Medicine·E W HarvilleW Rogan
Jan 22, 2002·Ecotoxicology and Environmental Safety·Isabel CorpasM Teresa Antonio
Mar 18, 2004·Reviews on Environmental Health·Linda M HeathJohn W Edwards

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