High affinity polyethylene oxide for improved biocompatibility

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
K D NelsonR C Eberhart

Abstract

Albumin passivation methods are based on the premise that a confluent layer of conformationally intact albumin will provide a biocompatible surface. However, albumin in contact with foreign surfaces tends to denature, and other proteins will adsorb to the surface, making the albumin passivation theory difficult to test. To overcome these two limitations, it was necessary to have a nondenaturing ligand specific for albumin attached to the surface by a long chain polyethylene oxide (PEO), which is known to have low protein binding. Clinical reports suggest no denaturation of albumin upon binding with warfarin, a drug known to have high albumin affinity. Thus, we tethered warfarin to glass.

Citations

Oct 22, 2013·Analytical Biochemistry·Ziyou CuiAldrin V Gomes
Dec 18, 2001·Journal of Biomedical Materials Research·Shwu Jen ChangYng Jiin Wang
Jul 8, 2015·Journal of Thrombosis and Haemostasis : JTH·I H JafferJ I Weitz
Aug 8, 2007·Journal of Vascular Surgery·Sumanas W Jordan, Elliot L Chaikof
Apr 1, 2020·Frontiers in Bioengineering and Biotechnology·Carlos A LabarrereGhassan S Kassab

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