PMID: 8358534Jun 1, 1993Paper

High-affinity uptake of noradrenaline in postsynaptic neurones

British Journal of Pharmacology
Saad Al-DamlujiK J Catt


1. Neurotransmitters released from nerve endings are inactivated by re-uptake into the presynaptic nerve terminals and possibly into neighbouring glial cells. While analysing the functional properties of alpha 1-adrenoceptors in the hypothalamus, we observed a high-affinity uptake process for noradrenaline in postsynaptic peptidergic neurones. 2. In primary hypothalamic cell cultures and in a hypothalamic neuronal cell line, [3H]-prazosin bound with high affinity and was displaced by unlabelled prazosin in concentrations of 10(-10) to 10(-7) M. However, at concentrations of unlabelled prazosin above 10(-7) M, there was a paradoxical increase in apparent [3H]-prazosin binding. 3. Methoxamine, an alpha 1-adrenoceptor ligand that is not subject to significant neuronal uptake, displaced [3H]-prazosin but did not cause the paradoxical increase in the apparent binding of [3H]-prazosin. Cooling the cells to 4 degrees C reduced the total amount of prazosin associated with the cells; under these conditions, methoxamine almost completely inhibited [3H]-prazosin binding to the cells. 4. In the presence of desipramine (DMI), unlabelled prazosin displaced [3H]-prazosin as before, but no paradoxical increase in apparent binding was seen abov...Continue Reading


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Jan 1, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·S B Ross, T Gosztonyi
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·W C WetselA Negro-Vilar
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L Z KrsmanovićK J Catt
Aug 1, 1988·The Journal of Comparative Neurology·E T Cunningham, P E Sawchenko
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W ReganB K Kobilka
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S CotecchiaB K Kobilka
Oct 1, 1988·The Journal of Endocrinology·S al-Damluji
Jul 1, 1987·Physiological Reviews·E E Müller
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Dec 20, 1974·Brain Research·M WilkinsonD R Inman
Nov 1, 1971·Journal of Neurochemistry·J T Coyle, J Axelrod
Jan 1, 1970·European Journal of Pharmacology·L L Iversen
Nov 1, 1970·British Journal of Pharmacology·L L Iversen, P J Salt
Jul 1, 1982·Brain Research Bulletin·G E HoffmanM Goldstein
Jan 1, 1983·Methods in Enzymology·W J ShoemakerW Vale
Apr 1, 1984·Biochemical Pharmacology·A BobikP J Little
Jan 1, 1983·General Pharmacology·K H Graefe, M Henseling
Oct 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·H Bönisch
Jan 1, 1983·Methods in Enzymology·C LoudesA Tixier-Vidal
Dec 1, 1963·British Journal of Pharmacology and Chemotherapy·L L IVERSEN
Aug 1, 1965·British Journal of Pharmacology and Chemotherapy·A S Burgen, L L Iversen

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