High altitude reduces infection rate of COVID-19 but not case-fatality rate

Respiratory Physiology & Neurobiology
Jose Segovia-JuarezGustavo F Gonzales

Abstract

Coronavirus disease 19 (COVID-19) is a pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It is suggested that life at high altitude may reduce COVID-19 infections and case-fatality rates (cases/deaths). We study data from Peru COVID-19 pandemics, which first case was recorded on March 6th, 2020. By June 13, 2020 there were 6498 deaths, and 224,132 SARS-CoV-2 positives. Using data from 185 capitals of provinces with altitudes ranging from 3 to 4342 m, we confirm previous reports that infection with COVID-19 at high altitude is reduced. However, case-fatality rate is not dependent of altitude. We have also presented first evidence that female protection towards death by COVID-19 is reduced as altitude of residence increases.

Citations

Aug 18, 2020·High Altitude Medicine & Biology·Claudio Intimayta-EscalanteIvan Hancco
Sep 6, 2020·The American Journal of Clinical Nutrition·Mona S Calvo
Aug 21, 2020·High Altitude Medicine & Biology·Orison O Woolcott, Richard N Bergman
Oct 31, 2020·The American Journal of Tropical Medicine and Hygiene·Eder Cano-PérezJuan Carlos Pozo-Palacios
Dec 20, 2020·Physiological Reports·Grégoire P MilletJohannes Burtscher
Jan 13, 2021·International Journal of Environmental Research and Public Health·Ennio CascettaLuigi Di Francesco
Feb 25, 2021·Scientific Reports·José Sebastião Cunha FernandesAna Cristina Rodrigues Lacerda
Mar 30, 2021·High Altitude Medicine & Biology·Timothy M ThomsonClaudia Machicado
Apr 4, 2021·International Journal of Environmental Research and Public Health·Jesús CastillaMarcela Guevara
May 22, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Victor J SamillanBrian R Zutta
Jun 11, 2021·Physiological Reports·Laura CardenasGustavo F Gonzales
Nov 2, 2021·Frontiers in Medicine·Rodrigo Hernán Tomas-GrauRosana Chehín
Nov 14, 2021·BMC Public Health·Adriana CamposRicardo Izurieta

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