PMID: 15332331Aug 31, 2004Paper

High and low grade oligodendrogliomas (ODG): correlation of amino-acid and glucose uptakes using PET and histological classifications

Journal of Neuro-oncology
F GiammarileD Frappaz

Abstract

Classification and treatment strategy of oligodendrogliomas (ODG) remain controversial. Imaging relies essentially on contrast enhancement using CT or MRI. The aim of our study was to use positron emission tomography (PET) using [18F]-flurodeoxyglucose (FDG) and [11C]-L-methyl-methionine (MET) to evaluate metabolic characteristics of ODG. We studied 19 patients with proven ODG, comparing standardized uptake values (SUV) and maximal tumor/contralateral normal tissues ratios (T/N). Imaging findings were compared with WHO, Smith and Daumas-Duport classifications. Uptake of FDG was decreased only in 8 patients, independently of grading, while MET uptake was always increased. MET uptake was significantly higher for high grade tumors grouped according to Smith or Daumas-Duport classifications, while no significant difference in MET uptake was found when using WHO classification. A different correlation was found between FDG and MET uptakes in normal tissues and high grade tumors. A trend for improved progression free survival was found for tumors that lacked contrast enhancement on MRI or those showing low FDG or MET uptake. In conclusion, MET appeared more sensitive than FDG to detect proliferation in ODG. The preferential protein m...Continue Reading

Citations

Sep 16, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I N ProninA A Postnov
Apr 23, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G ErbI J Namer
Jan 13, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Bálint AlkonyiCsaba Juhász
Dec 16, 2011·Journal of Neuro-oncology·Cécile ColavolpeEric Guedj
Dec 21, 2014·Brain Tumor Pathology·Hirokazu TakamiNobuhito Saito
Oct 13, 2006·British Journal of Cancer·C WalkerP C Warnke
Mar 29, 2006·Current Oncology Reports·Paul D Brown
Jul 6, 2006·Journal of Neuro-oncology·Abderrahmane HamlatYvon Guegan
Oct 22, 2020·Journal of Neurology·Dimitri RenardJean Sebastien Guillamo
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·J Gregory Cairncross
Oct 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Cheolwon SuhBong-Jae Lee
Jun 13, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Thomas VielAndreas H Jacobs

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