PMID: 3744440Jan 1, 1986Paper

High antibody response to autologous type II collagen is restricted to H-2q

Immunogenetics
R HolmdahlC Hansen

Abstract

The incidence of arthritis and the antibody response to mouse and to rat type II collagen after immunization with native rat type II collagen was studied in different mouse strains, including wild mouse-derived strains belonging to the H-2p/H-2q family. High serum levels of antibodies to mouse and rat type II collagen were seen only in H-2q mice, whereas mice belonging to the p, w3, w5, and w17 haplotypes displayed low type II collagen-specific antibody responses. Mice from three different H-2q-carrying strains (DBA/1, NFR/N, and B10.G) with different non-major histocompatibility complex genes were all susceptible to collagen arthritis, but they displayed a varying incidence of arthritis and varying clinical features. No arthritis was seen in non-H-2q mice, except in the B10.CAS2 strain where a few mice developed arthritis despite very low serum levels of type II collagen-specific antibodies. We conclude that small differences in the A beta chain of class II transplantation antigens are of importance for the development of arthritis and for the stimulation of a high response after immunization with type II collagen.

References

Jan 1, 1975·Archives of Biochemistry and Biophysics·B D SmithR Swarm
Jan 1, 1986·Arthritis and Rheumatism·R HolmdahlL Klareskog
Mar 1, 1982·The Journal of Clinical Investigation·J M StuartA H Kang
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Citations

Nov 10, 1998·European Journal of Immunology·J JirholtR Holmdahl
Oct 11, 2001·Arthritis and Rheumatism·L Jansson, R Holmdahl
Dec 1, 1986·Agents and Actions·R HolmdahlM Andersson
Jul 1, 1992·Journal of Neuroimmunology·I HanssonR Mattsson
Sep 1, 1991·Human Immunology·H J Garchon, J F Bach
Jun 1, 2002·Ageing Research Reviews·Rikard HolmdahlHisakata Yamada
Apr 7, 1998·Clinical and Experimental Immunology·L SvenssonL Jansson
Jul 17, 2001·Immunology·M EhingerR Holmdahl
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R HolmdahlL Andersson
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·V MalmströmR Holmdahl
Aug 1, 1994·The Journal of Experimental Medicine·E MichaëlssonR Holmdahl
Sep 1, 1995·Journal of Internal Medicine·L KlareskogG Holm
Dec 1, 1990·Immunological Reviews·R HolmdahlJ A Mo
Aug 18, 1999·Immunological Reviews·R HolmdahlL Fugger
Oct 9, 2012·Annals of the Rheumatic Diseases·Johan BäcklundRikard Holmdahl
Aug 1, 1990·Annals of the Rheumatic Diseases·M J RowleyI R Mackay
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·R A McIndoeL Hood
Jul 1, 1994·European Journal of Immunology·U BrunsbergR Holmdahl
May 1, 1994·European Journal of Immunology·L Jansson, R Holmdahl
Dec 2, 2005·Arthritis and Rheumatism·Alexandra P TreschowShohreh Issazadeh-Navikas
Jan 20, 2007·European Journal of Immunology·Robert Bockermann, Rikard Holmdahl
Oct 2, 2007·Arthritis and Rheumatism·Kutty Selva NandakumarRikard Holmdahl

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