High apoB/apoA-I ratio is associated with increased progression rate of carotid artery intima-media thickness in clinically healthy 58-year-old men: experiences from very long-term follow-up in the AIR study

Atherosclerosis
C Schmidt, J Wikstrand

Abstract

The aim of the present study was to investigate the relationship between atherosclerotic progression rate as measured by carotid artery IMT during very long-term follow-up in clinically healthy men and a number of baseline risk factors of potential importance for atherosclerosis progression including apoA-I, apoB, apoB/apoA-I ratio, other lipid variables including LDL particle size, body composition variables, blood pressure, smoking, fasting blood glucose and insulin, and also hsCRP. Low-density lipoprotein (LDL) is associated with increased carotid IMT progression rate during long-term follow-up, whereas the relationship between newer biomarkers such as apoB/apoA-I ratio and carotid artery IMT progression rate has been less investigated. 58-year-old men identified by screening in the community (n=391) with varying degrees of obesity and insulin sensitivity were examined with high-resolution B-mode ultrasound at baseline and after 3, and 8.9 years of follow-up (n=305 investigated after 8.9 years). The carotid arteries were examined bilaterally, and the mean intima-thickness was calculated for 10mm sections of the composite of common carotid arteries and bulbs (IMT(composite)). Serum levels of apoB and apoA-I were measured usin...Continue Reading

References

Mar 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·L BokemarkUNKNOWN Atherosclerosis and Insulin Resistance sstudy (AIR)
Aug 31, 2006·The Journal of Clinical Endocrinology and Metabolism·Asa TivestenBjörn Fagerberg
Mar 27, 2007·JAMA : the Journal of the American Medical Association·John R CrouseUNKNOWN METEOR Study Group
Jul 17, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Göran Walldius, Ingmar Jungner
Aug 1, 2007·Journal of Vascular Surgery·Kosmas I ParaskevasDimitri P Mikhailidis

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Citations

Dec 6, 2012·Nature Communications·Fredrik H KarlssonJens Nielsen
Dec 10, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Bum Joon KimSun U Kwon
Sep 15, 2011·European Journal of Clinical Investigation·Sarah A BovenbergManuel Castro Cabezas
Jan 5, 2012·Scandinavian Journal of Urology and Nephrology·S LundbergS H Jacobson
Sep 16, 2011·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·Thomas Reinehr, Rainer Wunsch
Mar 2, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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