High Aspect Ratio Nanostructures Kill Bacteria via Storage and Release of Mechanical Energy

ACS Nano
Denver P LinklaterElena P Ivanova

Abstract

The threat of a global rise in the number of untreatable infections caused by antibiotic-resistant bacteria calls for the design and fabrication of a new generation of bactericidal materials. Here, we report a concept for the design of antibacterial surfaces, whereby cell death results from the ability of the nanofeatures to deflect when in contact with attaching cells. We show, using three-dimensional transmission electron microscopy, that the exceptionally high aspect ratio (100-3000) of vertically aligned carbon nanotubes (VACNTs) imparts extreme flexibility, which enhances the elastic energy storage in CNTs as they bend in contact with bacteria. Our experimental and theoretical analyses demonstrate that, for high aspect ratio structures, the bending energy stored in the CNTs is a substantial factor for the physical rupturing of both Gram-positive and Gram-negative bacteria. The highest bactericidal rates (99.3% for Pseudomonas aeruginosa and 84.9% for Staphylococcus aureus) were obtained by modifying the length of the VACNTs, allowing us to identify the optimal substratum properties to kill different types of bacteria efficiently. This work highlights that the bactericidal activity of high aspect ratio nanofeatures can outp...Continue Reading

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Citations

Jul 25, 2019·Critical Reviews in Biotechnology·Guangshun YiYugen Zhang
Jul 28, 2020·Small·Zhiling ZhuWilliam W Yu
Aug 19, 2020·Nature Reviews. Microbiology·Denver P LinklaterElena P Ivanova
Apr 8, 2020·International Journal of Nanomedicine·David J BannerTolou Shokuhfar
May 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Elena P IvanovaRussell J Crawford
Oct 24, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guangshun YiYugen Zhang
Nov 13, 2020·Advanced Materials·Denver P LinklaterElena P Ivanova
Dec 18, 2020·Biophysical Journal·Amar VelicPrasad K D V Yarlagadda
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Jianqiao LiuYujin Tang
Feb 6, 2021·Drug Delivery and Translational Research·Yujie CaiZhen Gu
Mar 2, 2021·Chemical Engineering Journal·Vignesh KumaravelSuresh C Pillai
Jun 3, 2021·International Journal of Molecular Sciences·Daniil V KladkoArtur Y Prilepskii
Jun 21, 2021·Colloids and Surfaces. B, Biointerfaces·Qianqian CuiDan Ge
Jun 8, 2018·Journal of the American Chemical Society·D Leonardo Gonzalez ArellanoAlejandro L Briseno
Jul 25, 2019·ACS Applied Materials & Interfaces·Viktor A PonomarevDmitry V Shtansky
Jul 8, 2019·ACS Biomaterials Science & Engineering·Jafar HasanPrasad K D V Yarlagadda
Apr 14, 2020·ACS Applied Materials & Interfaces·Jagriti SinghProsenjit Sen
May 28, 2020·ACS Nano·Paul Mulvaney
Sep 14, 2021·Advanced Materials·Martyna MichalskaIoannis Papakonstantinou
Jan 29, 2022·ACS Applied Materials & Interfaces·August KohlsSi-Yang Zheng

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