High association of human herpesvirus 8 in large-plaque parapsoriasis and mycosis fungoides

Archives of Dermatology
Alexander KreuterThilo Gambichler

Abstract

To investigate the presence of human herpesvirus 8 (HHV-8) in lesional skin of German patients with large-plaque parapsoriasis (LPP) or mycosis fungoides (MF). The pathogenetic relevance of HHV-8 in cutaneous T-cell lymphoma is controversial. Recently, a highly significant association of HHV-8 in LPP was found, which suggests a role in the pathogenesis of this disease. Retrospective study of the presence of HHV-8 in German patients with lymphoproliferative diseases. Dermatologic clinic at a university hospital of the Ruhr University Bochum, Bochum, Germany. Fifty-three patients treated for lymphoproliferative skin diseases were included in the study, including 14 patients with LPP, 31 with different stages of MF, and 8 with lymphomatoid papulosis (LyP). Twenty-three patients with Kaposi sarcoma (KS) made up the positive control group, and 10 patients with atopic dermatitis served as negative controls. The presence of HHV-8 was analyzed from paraffin-embedded lesional tissue samples using a nested polymerase chain reaction for the open reading frame (ORF) 26 and with immunohistochemical staining for the latency-associated nuclear antigen (LANA) encoded by ORF 73. A high association of HHV-8 infection in both lymphoproliferative ...Continue Reading

Citations

Aug 21, 2013·Toxins·Andreas Willerslev-OlsenNiels Odum
Jun 29, 2013·Clinics in Dermatology·Judah J MirvishLarisa J Geskin
Aug 10, 2010·Journal of the American Academy of Dermatology·Ezra D MirvishLarisa J Geskin
Jan 17, 2015·Journal of Experimental & Clinical Cancer Research : CR·Paola Cordiali-FeiFabrizio Ensoli
Mar 17, 2017·Anais Brasileiros De Dermatologia·Maria Carolina Prado Fleury BarianiTiago Arantes Pereira
Apr 1, 2020·Journal of Immunotherapy·Thilo GambichlerKerstin Lang

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