High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis?

Arthritis Research & Therapy
Ranjeny ThomasAndrew P Cope

Abstract

Self-reactive T cells with low signalling capacity through the T-cell receptor were recently observed in the SKG mouse model of rheumatoid arthritis (RA) and have been linked to a spontaneous mutation in the ZAP-70 signal transduction molecule. Here we hypothesize that similar mechanisms also drive RA, associated with an abnormal innate and adaptive immune response driven by nuclear factor-kappaB activation and tumour necrosis factor secretion. Similar to the essential role played by pathogens in SKG mice, we propose that HLA-associated immunity to chronic viral infection is a key factor in the immune dysregulation and joint inflammation that characterize RA.

References

Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J RoudierD A Carson
Apr 24, 1987·Cell·J W KapplerP Marrack
Oct 1, 1994·The Journal of Experimental Medicine·C CauxJ Banchereau
Jun 1, 1995·European Journal of Immunology·M E AllenP A Bacon
Jul 1, 1997·Immunology Today·C Ardavín
Dec 31, 1997·The Journal of Clinical Investigation·K P MacDonaldR Thomas
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·B FoxwellM Feldmann
Oct 23, 1998·The Journal of Experimental Medicine·B LudewigR M Zinkernagel
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·R KhannaD J Moss
Jun 23, 2000·The Journal of Clinical Investigation·I K CampbellI P Wicks
Feb 13, 2001·The Journal of Clinical Investigation·J HiscottP Génin
Aug 18, 2001·Arthritis and Rheumatism·P P TakG S Firestein
Jul 29, 2004·The Journal of Experimental Medicine·Michael R EhrensteinClaudia Mauri
Aug 4, 2004·Autoimmunity Reviews·Nathalie BalandraudChantal Roudier
Feb 22, 2005·Autoimmunity Reviews·Shigemasa Sawada, Masami Takei
Mar 4, 2005·Arthritis Research & Therapy·Lois L CavanaghRanjeny Thomas
Apr 9, 2005·Arthritis and Rheumatism·Sophie Tezenas du MontcelFrançoise Clerget-Darpoux
Nov 8, 2005·Nature Genetics·Torkel VangNunzio Bottini
Feb 14, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Se-Ran YangIrfan Rahman
Mar 2, 2006·Arthritis and Rheumatism·Cornelia M WeyandPaul J Kurtin
May 16, 2006·Seminars in Immunology·Nunzio BottiniTomas Mustelin
Sep 5, 2006·Nature Immunology·Roberto BonasioUlrich H von Andrian
Nov 18, 2006·Nature Immunology·Matthew J RobinsonCaetano Reis e Sousa
Jan 18, 2007·Expert Opinion on Therapeutic Targets·Brendan O'SullivanRanjeny Thomas

❮ Previous
Next ❯

Citations

Dec 6, 2011·Cellular & Molecular Immunology·Chaoying HuDongqing Zhang
Mar 16, 2012·Immunology and Cell Biology·Shimon SakaguchiRanjeny Thomas
May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Karnail SinghJörg J Goronzy
Oct 20, 2009·Arthritis Research & Therapy·Jörg J Goronzy, Cornelia M Weyand
Feb 5, 2013·Arthritis Research & Therapy·Ranjeny Thomas
Jan 8, 2014·Nature Reviews. Rheumatology·Tamás KobezdaZoltán Szekanecz
Apr 26, 2011·FEBS Letters·Saba Alzabin, Richard O Williams
Sep 18, 2009·Annals of the New York Academy of Sciences·Guzman M Renato
Jan 5, 2010·American Journal of Human Genetics·Manuel A R FerreiraNicholas G Martin
Dec 28, 2018·Clinical and Experimental Immunology·P WehrR Thomas
Jun 12, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shatakshi SoodRose Zamoyska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.