High baseline soluble urokinase plasminogen activator receptor (suPAR) serum levels indicate adverse outcome after resection of pancreatic adenocarcinoma

Carcinogenesis
Sven H LoosenTom Luedde

Abstract

Surgical resection represents the only potentially curative therapy for patients with pancreatic adenocarcinoma (PDAC), an aggressive malignancy with a very limited 5-year survival rate. However, even after complete tumor resection, many patients are still facing an unfavorable prognosis underlining the need for better preoperative stratification algorithms. Here, we explored the role of the secreted glycoprotein soluble urokinase plasminogen activator receptor (suPAR) as a novel circulating biomarker for patients undergoing resection of PDAC. Serum levels of suPAR were measured by ELISA in an exploratory as well as a validation cohort comprising a total of 127 PDAC patients and 75 healthy controls. Correlating with a cytoplasmic immunohistochemical expression of uPAR in PDAC tumor cells, serum levels of suPAR were significantly elevated in PDAC patients compared to healthy controls and patient with PDAC precursor lesions. Importantly, patients with high preoperative suPAR levels above a calculated cut-off value of 5.956 ng/ml showed a significantly reduced overall survival after tumor resection. The prognostic role of suPAR was further corroborated by uni- and multivariate Cox-regression analyses including parameters of system...Continue Reading

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Citations

Nov 28, 2020·Scandinavian Journal of Gastroenterology·Anu AronenJohanna Laukkarinen
Jul 3, 2021·International Journal of Molecular Sciences·Christoph RoderburgTom Luedde
Dec 21, 2021·Frontiers in Immunology·Line Jee Hartmann RasmussenJesper Eugen-Olsen

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Methods Mentioned

BETA
surgical resection
imaging techniques
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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