High BDNF serum levels are associated to good cognitive functioning in bipolar disorder

European Psychiatry : the Journal of the Association of European Psychiatrists
E MoraM Mur

Abstract

Neurotrophins such as brain-derived neurotrophic factor (BDNF), inflammation and oxidative damage may contribute to the pathophysiology of bipolar disorder (BD) in terms of illness activity. To date, there is a lack of studies linking the cognitive impairment observed in BD with these neurobiological mechanisms. This study aimed to investigate the role of these neurobiological factors in clinical and cognitive outcomes in a sample of bipolar individuals. We measured serum BDNF, cytokines and oxidative stress markers in a sample of 133 individuals: 52 euthymic bipolar patients, 32 manic patients and 49 healthy controls. They were all assessed with a comprehensive cognitive battery. Sociodemographic and clinical data were collected. Multiple linear regression models were built to study associations of neurotrophins and inflammatory and oxidative measures with cognitive functioning. BDNF levels were decreased in euthymic (p = 0.039) and manic (p < 0.001) individuals. Conversely, inflammatory (interleukin 6 (IL-6)) (p = 0.019) and oxidative stress (p = 0.003) measures were increased in bipolar individuals compared to controls. BDNF levels were associated with executive functioning (β = 0.01, p = 0.02) and verbal memory (β = 0.013, ...Continue Reading

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Citations

Aug 24, 2019·Frontiers in Cellular Neuroscience·Magdalena MirandaPedro Bekinschtein
Dec 29, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Thibaut GelleMurielle Girard
Aug 18, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Burak BaykaraNeslihan Inal Emiroglu
Apr 21, 2021·The European Journal of Neuroscience·Ellen DoneyCaroline Menard
Jun 12, 2021·Journal of Biomedical Science·Gregory H JonesRodrigo Machado-Vieira

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