High bicarbonate dialysate in haemodialysis patients: effects on acidosis and nutritional status

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
A J WilliamsJ Clarke

Abstract

Metabolic acidosis adversely affects both protein and bone metabolism in patients with chronic renal failure, and could also affect morbidity and mortality. This trial aimed to investigate the effects of different dialysate bicarbonate concentrations on control of acid base balance, and nutritional status. Forty-six stable haemodialysis patients were dialysed using LowBic. (30 mmol/l) or HighBic. (40 mmol/l) bicarbonate dialysate in a single blind double crossover trial, of two consecutive six-month periods. Blood gas analysis, anthropometric indices and dialysis dose were measured, in addition to biochemical indices. Predialysis 'arterial' plasma pH values were significantly higher when using the HighBic. dialysate (LowBic. 7.38 +/- 0.05, HighBic. 7.43 +/- 0.04, P < 0.001), as was predialysis serum total CO2 at all times during the study (P < 0.01). Kt/V, (LowBic. 1.27 +/- 0.19, HighBic. 1.27 +/- 0.25), urea generation rates (UGR) (LowBic. 1.99 +/- 0.77, HighBic. 1.92 +/- 0.77 mmol/min), and normalized protein catabolic rate (NPCR) (LowBic. 1.04 +/- 0.26, HighBic. 0.99 +/- 0.28 g/kg/day) did not differ, and values of parathroid hormone (PTH) were comparable. Triceps skinfold thickness (TSF) showed a significant change (LowBic....Continue Reading

Citations

Jun 8, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jeffrey A Kraut, Nicolaos E Madias
Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mariano FerianiUNKNOWN Study Group
Mar 3, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael R WiederkehrReto Krapf
Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco LocatelliMohammed Yaqoob
Feb 3, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ricardo M HeguilénAmelia R Bernasconi
Aug 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Csaba P Kovesdy
May 29, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Maurizio MuscaritoliFilippo Rossi Fanelli
Jun 12, 2010·Current Opinion in Nephrology and Hypertension·Muhammad M Yaqoob
May 13, 2011·Nephron. Clinical Practice·Robert MactierCormac Breen
Jul 18, 2009·Journal of the American Society of Nephrology : JASN·Ione de Brito-AshurstMuhammad M Yaqoob
May 28, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Francesca TentoriFriedrich K Port
Mar 30, 2012·Kidney International·George A KaysenUNKNOWN FHN Trial Group
Mar 15, 2006·Kidney International·K LomashviliW C O'Neill
Jan 14, 2000·Kidney International. Supplement·J D LoudenT H Goodship
Feb 12, 2004·Kidney International. Supplement·Rajnish MehrotraMarsha Wolfson
Oct 9, 2003·Kidney International. Supplement·George A Kaysen
Jan 22, 2005·Seminars in Dialysis·Kamyar Kalantar-ZadehJoel D Kopple
Oct 6, 2004·Seminars in Dialysis·Cheuk-Chun Szeto, Kai-Ming Chow
Jan 31, 2006·Hemodialysis International·Ramin SamTodd S Ing
Mar 23, 2005·Critical Care Clinics·Jean-Philippe Lafrance, Martine Leblanc
Aug 3, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ione de-Brito AshurstMuhammad M Yaqoob
Aug 3, 2000·Seminars in Dialysis·J P Brady, J A Hasbargen
Sep 1, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Maurizio BossolaGiovanna Luciani
Mar 16, 2017·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Mandip PanesarBrian Murray
Jan 27, 2007·The Cochrane Database of Systematic Reviews·P RoderickC Tomson
Apr 4, 2019·Seminars in Dialysis·John A SargentF John Gennari
Feb 2, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Muhammad M Yaqoob
Feb 9, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Matthew K AbramowitzThomas H Hostetter
Mar 5, 2020·The International Journal of Artificial Organs·John K LeypoldtJacek Waniewski
Feb 26, 2009·The International Journal of Artificial Organs·M StosovicJ Marinkovic
Nov 25, 2016·Journal of the American Society of Nephrology : JASN·Matthew K Abramowitz
May 19, 2020·Hemodialysis International·Farnaz HefzollahMehdi Mahmudpour
Jun 10, 2018·Seminars in Dialysis·Carlo BasileCarlo Lomonte
Nov 26, 2015·Seminars in Dialysis·David Tovbin, Richard A Sherman
Feb 4, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasiliki KaravaNikoleta Printza
Jun 16, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jeffrey A Kraut, Ira Kurtz
Sep 2, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J UribarriG Yan

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