High Bleeding Risk Patients Treated with Very Thin-Strut Biodegradable Polymer or Thin-Strut Durable Polymer Drug-Eluting Stents in the BIO-RESORT Trial

Cardiovascular Drugs and Therapy
Paolo ZoccaClemens von Birgelen

Abstract

Patients with high bleeding risk (HBR) who undergo percutaneous coronary intervention also have an increased risk of ischemic events and represent an overall high-risk population. The coating of durable polymer drug-eluting stents (DP-DES) may induce inflammation and delay arterial healing, which might be reduced by novel biodegradable polymer DES (BP-DES). We aimed to evaluate the safety and efficacy of treating HBR patients with very thin-strut BP-DES versus thin-strut DP-DES. Participants in BIO-RESORT (NCT01674803), an investigator-initiated multicenter, randomized all-comers trial, were treated with very thin-strut BP-DES (Synergy or Orsiro) or thin-strut DP-DES (Resolute Integrity). For the present analysis, patients were classified following HBR criteria based on previous trials. The primary endpoint was target vessel failure: a composite of cardiac death, target vessel-related myocardial infarction, or target vessel revascularization at 1 year. Of all 3514 patients, 1009 (28.7%) had HBR. HBR patients were older (p < 0.001) and had more co-morbidities than non-HBR patients (p < 0.001). At 1-year follow-up, HBR patients had significantly higher rates of target vessel failure (6.7 vs. 4.2%, p = 0.003), cardiac death (1.9 v...Continue Reading

Associated Clinical Trials

May 13, 2021·Daniel Fernando Zazueta Salido, Daniel Fernando Zazueta Salido

References

Jul 4, 2006·Journal of the American College of Cardiology·Michael JonerRenu Virmani
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
Feb 10, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Pascal VranckxPatrick W Serruys
Apr 10, 2015·Circulation. Cardiovascular Interventions·Dean J KereiakesKeith D Dawkins
Oct 16, 2015·The New England Journal of Medicine·Philip UrbanUNKNOWN LEADERS FREE Investigators
Aug 23, 2017·The American Journal of Cardiology·M Chadi AlraiesRon Waksman
Aug 24, 2017·Lancet·Robert A ByrneAdnan Kastrati

❮ Previous
Next ❯

Citations

Jun 19, 2019·Future Cardiology·Ofer Kobo, Ariel Roguin
Apr 23, 2021·Expert Review of Cardiovascular Therapy·Tanveer MirLuis Afonso
Apr 13, 2021·International Journal of Pharmaceutics·Alistair McQueenSean McGinty

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary
coronary artery bypass

Clinical Trials Mentioned

NCT01674803
NCT03112707
NCT02605447
NCT02623140

Software Mentioned

LEADERS FREE
RESORT
SPSS
BIO
Synergy
EVOLVE
Endeavor

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here