High brain acid soluble protein 1(BASP1) is a poor prognostic factor for cervical cancer and promotes tumor growth

Cancer Cell International
Huiru TangHeping Li

Abstract

The aim of this study was to determine whether brain abundant membrane attached signal protein 1 (BASP1) is a valuable prognostic biomarker for cervical cancer and whether BASP1 regulates the progression of cervical cancer. Quantitative real-time PCR, western blotting, and immunohistochemistry were used to determined BASP1 levels. Statistical analyses were used to examine whether BASP1 was a prognostic factor for patients with cervical cancer. The MTT assay, colony formation assay, cell cycle assay, anchorage-independent growth assay, and a tumor xenograft model were used to determine the role of BASP1 in the proliferation and tumorigenicity of cervical cancer. Brain abundant membrane attached signal protein 1 was upregulated in cervical cancer tissues and cells, and BASP1 expression levels were higher in patients that had died during follow-up compared with those that survived. There was a positive correlation between BASP1 expression and clinical stage (p < 0.001), T classification (p < 0.001), N classification (p < 0.05), and survival or mortality (p < 0.05). Patients with higher BASP1 expression had a shorter overall survival time. Cox regression analysis shown BSAP1 was an unfavorable prognostic factor for patients with ce...Continue Reading

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Citations

May 7, 2019·Frontiers in Oncology·Markus Hartl, Rainer Schneider
Jun 19, 2019·Journal of Experimental & Clinical Cancer Research : CR·Qing YangBinsheng Fu
Apr 27, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mehrdad KhajaviRobert J D'Amato

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Methods Mentioned

BETA
xenograft
immunoprecipitation assay
transfection
xenografts

Software Mentioned

GSEA
SPSS

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