High Burden of Human Papillomavirus (HPV) Infection among Young Women in KwaZulu-Natal, South Africa

PloS One
Sumayyah EbrahimAnna-Lise Williamson

Abstract

HPV infection causes cervical cancer, yet information on prevalence and risk factors for HPV in Africa remain sparse. This study describes the prevalence of HPV genotypes and risk factors associated with HPV among young women ≤ 30 years of age in KwaZulu-Natal (KZN), South Africa. Cervicovaginal lavage samples were tested for HPV genotypes in 224 women enrolled in a prospective cohort study. Clinical, behavioural and demographic data were collected. We measured prevalence of HPV genotypes and using logistic regression, examined for factors associated with HPV. Median age of participants was 21 years [interquartile range (IQR):18-23]. The overall prevalence of HPV was 76.3% (171/224) with multiple and single genotypes prevalent in 56.3% and 20.1% of women respectively. Proportion of women with high-risk genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56 and 58) was 54.5%. Women not living with their partner [adjusted odds ratio (aOR)] = 3.42 95% CI1.22-9.60; p = 0.019), was significantly associated with HPV infection and high-risk HPV genotype infection. The high burden of HPV and associated risk behaviours highlight the need to intensify behavioural interventions to prevent HPV acquisition in young women. The large scale deliver...Continue Reading

References

Sep 9, 2000·The Journal of Infectious Diseases·K K ThomasL A Koutsky
Feb 7, 2003·The New England Journal of Medicine·Nubia MuñozUNKNOWN International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
Jan 1, 2004·The Journal of Infectious Diseases·Trudee A TarkowskiElizabeth R Unger
Apr 13, 2004·Sexually Transmitted Diseases·Landon MyerLouise Kuhn
Oct 13, 2005·Vaccine·Margaret Stanley
Jun 23, 2006·The New England Journal of Medicine·Rachel L WinerLaura A Koutsky
Sep 5, 2006·Vaccine·Nubia MuñozLutz Gissmann
Dec 14, 2007·Journal of Clinical Microbiology·Dianne J MaraisAnna-Lise Williamson
Feb 13, 2009·Best Practice & Research. Clinical Obstetrics & Gynaecology·Charles S MorrisonLaShawn B Jones
Aug 25, 2010·International Journal of Cancer. Journal International Du Cancer·Morgan MarksDavid D Celentano
Nov 5, 2010·International Journal of Epidemiology·Quarraisha Abdool KarimSalim S Abdool Karim
Nov 16, 2010·The Lancet Infectious Diseases·Nienke J VeldhuijzenJanneke Hhm van de Wijgert
Jan 25, 2011·The Journal of Infectious Diseases·Nicole G CamposMark Schiffman
Dec 14, 2011·Archives of Gynecology and Obstetrics·Krishnakumar VinodhiniKalimuthusamy Natarajaseenivasan
Jun 5, 2013·Obstetrics and Gynecology Clinics of North America·Leda GattocKevin Ault
Aug 24, 2013·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·K RichterG Dreyer
Aug 24, 2013·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·I MoodleyL Denny

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Citations

Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ninghong JiangLong Sui
Feb 23, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Yara Priscilla BuleRui Medeiros
Apr 26, 2017·Expert Review of Anti-infective Therapy·Ralph-Sydney Mboumba BouassaLaurent Bélec
Jul 27, 2021·Tropical Medicine & International Health : TM & IH·Hilary WhitworthDeborah Watson-Jones

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Methods Mentioned

BETA
lavage
Genotyping
contraception

Software Mentioned

SAS

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