High burden of rotavirus gastroenteritis in young children in rural western Kenya, 2010-2011

The Pediatric Infectious Disease Journal
Sammy KhagayiKayla F Laserson

Abstract

Diarrhea is a leading cause of hospitalization and death in children <5 years of age. To facilitate evaluation of the impact of rotavirus vaccine introduction in western Kenya, we estimated baseline rates of rotavirus-associated hospitalization and mortality among children <5 years of age. From January 2010 to December 2011, we collected demographic, clinical and laboratory data for children <5 years of age seeking care at the district hospital and 2 outpatient facilities within a Health and Demographic Surveillance System (HDSS). Children with acute gastroenteritis (AGE), defined as ≥3 loose stools and/or ≥1 episode of unexplained vomiting followed by loose stool within a 24-hour period, were asked to provide a stool sample for rotavirus ELISA testing. Rates of rotavirus-associated hospitalization and mortality were estimated using time of residence in the HDSS to calculate person-years of observation. To estimate the rotavirus-associated mortality rate, we applied the percentage positive for rotavirus among AGE hospitalizations to verbal autopsy estimates of diarrhea deaths in the HDSS. There were 4991 hospitalizations of children <5 years of age; 1134 (23%) were for AGE and stool specimens were obtained from 790 (70%). Rotav...Continue Reading

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Citations

Sep 21, 2016·Journal of Medical Virology·Ernest A WanderaYoshio Ichinose
Jul 22, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sammy KhagayiJennifer R Verani
Sep 24, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Grieven P OtienoD James Nokes

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