High but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces 'compulsive' lever-pressing in rats

Behavioural Brain Research
Oded KlavirDaphna Joel

Abstract

The anti-compulsive effects of high and low frequency stimulation (LFS, HFS) of the entopeduncular nucleus and globus pallidus (the rat's equivalent, respectively, of the primate's internal and external segments of the globus pallidus) were assessed in the signal attenuation rat model of obsessive-compulsive disorder (OCD). HFS, but not LFS, of the two nuclei exerted an anti-compulsive effect, suggesting that HFS of either segment of the globus pallidus may provide an additional therapeutic strategy for OCD.

References

Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Mar 1, 1995·International Clinical Psychopharmacology·D J SteinE Hollander
Apr 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·M PiccinelliG Wilkinson
Aug 1, 1994·Brain : a Journal of Neurology·C D Marsden, J A Obeso
Apr 1, 1996·Clinical Neuropharmacology·O T DolbergJ Zohar
Jul 1, 1997·Annals of Neurology·P KrackA L Benabid
Feb 9, 1999·Journal of Neurosurgery·D KondziolkaL D Lunsford
Mar 20, 1999·The Journal of Clinical Psychiatry·T A Pigott, S M Seay
Feb 25, 2000·Biological Psychiatry·D J Stein
Dec 24, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daphna Joel, Julia Doljansky
Nov 14, 2003·The New England Journal of Medicine·Paul KrackPierre Pollak
Jan 20, 2004·Journal of Chemical Neuroanatomy·Volker SturmJoachim Klosterkötter
Jan 27, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Yasin Temel, Veerle Visser-Vandewalle
Jan 28, 2004·Stereotactic and Functional Neurosurgery·Kendall H LeeUhnoh Kim
Feb 6, 2004·Psychological Review·Henry Szechtman, Erik Woody
Apr 2, 2004·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Antonio Carlos LopesEurípedes Constantino Miguel
Apr 21, 2004·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Cameron C McIntyreJerrold L Vitek
May 12, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Cameron C McIntyreJerrold L Vitek
Jul 27, 2004·Depression and Anxiety·H Blair SimpsonRaphael Campeas
Aug 10, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Jerrold L VitekRoy A E Bakay
Sep 9, 2004·Journal of Neurosurgery·Kendall H LeeUhnoh Kim
Sep 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Kazumichi YamadaSatoshi Goto
Feb 8, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Linda AckermansUNKNOWN Dutch Flemish Tourette Surgery Study Group
Feb 21, 2006·Experimental Neurology·Jianyu ZhangJerrold L Vitek
Jul 1, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Günther DeuschlValerie Voon
Jul 21, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin D GreenbergSteven A Rasmussen
Nov 10, 2006·The New England Journal of Medicine·Andreas KupschUNKNOWN Deep-Brain Stimulation for Dystonia Study Group
Feb 27, 2007·Behavioural Brain Research·Lior BrimbergDaphna Joel

❮ Previous
Next ❯

Citations

Feb 12, 2013·Behavioural Brain Research·Marianne KlankerDamiaan Denys
Jul 13, 2012·Science Translational Medicine·Clement Hamani, Yasin Temel
Jun 23, 2011·Annual Review of Neuroscience·Paul E Holtzheimer, Helen S Mayberg
Jun 2, 2012·Expert Opinion on Drug Discovery·Kurt Leroy Hoffman
Jan 8, 2013·Brain Research Bulletin·Mónica Méndez-DíazOscar Prospéro-García
Sep 20, 2011·Neuroscience·N Albelda, D Joel
Sep 1, 2015·Current Behavioral Neuroscience Reports·Maarten van WestenDamiaan Denys
Apr 30, 2011·Neuroscience and Biobehavioral Reviews·Noa Albelda, Daphna Joel
Sep 17, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Prateek AgarwalAntonios Mammis
Dec 13, 2019·Pharmacological Reviews·Henry SzechtmanKurt Leroy Hoffman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.