High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer

Oncotarget
Jose Luis Lopez-GuerraAmancio Carnero

Abstract

Reliable biological markers that predict breast cancer (BC) outcomes after multidisciplinary therapy have not been fully elucidated. We investigated the association between casein kinase 1 epsilon (CK1ε) and the risk of recurrence in patients with BC. Using 168 available tumor samples from patients with BC treated with surgery +/- chemo(radio)therapy, we scored the CK1ε expression as high (≥ 1.5) or low (<1.5) using an immunohistochemical method. Kaplan-Meier analysis was performed to assess the risk of relapse, and Cox proportional hazards analyses were utilized to evaluate the effect of CK1ε expression on this risk. The median age at diagnosis was 60 years (range 35-96). A total of 58% of the patients underwent breast conservation surgery, while 42% underwent mastectomy. Adjuvant chemotherapy and radiation therapy were administered in 101 (60%) and 137 cases (82%), respectively. Relapse was observed in 24 patients (14%). Multivariate analysis found high expression of CK1ε to be associated with a statistically significant higher disease-free survival (DFS) in BC patients with wild-type p53 (Hazard ratio [HR] = 0.33; 95% CI, 0.12-0.91; P = 0.018) or poor histological differentiation ([HR] = 0.34; 95% CI, 0.12-0.94; P = 0.039) o...Continue Reading

References

Oct 12, 1999·Nature·J M PetersJ M Graff
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·C SakanakaL T Williams
Jun 27, 2001·The Journal of Biological Chemistry·M KishidaA Kikuchi
Oct 9, 2002·The American Journal of Pathology·Henry F FriersonGarret M Hampton
Feb 22, 2005·Cellular Signalling·Uwe KnippschildMartin Stöter
Oct 6, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y-H YangT-Y Shieh
Jan 9, 2007·Current Opinion in Genetics & Development·Paul Polakis
Apr 12, 2007·Carcinogenesis·Maria V GuijarroAmancio Carnero
Jul 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masuko Katoh, Masaru Katoh
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jer-Yen Yang, Mien-Chie Hung
Jan 22, 2010·Current Cancer Drug Targets·Fabian ZanellaAmancio Carnero
Oct 15, 2009·World Journal of Gastrointestinal Oncology·Cristina Modak, Jianyuan Chai
May 21, 2011·The Journal of Pathology·Sonia Molina-PineloAmancio Carnero
Jul 21, 2011·Cell Cycle·Irene FerrerAmancio Carnero
Nov 20, 2013·Cancer Research·Sejeong ShinSang-Oh Yoon
Feb 22, 2014·International Journal of Molecular Sciences·Shu-Hui LinShun-Fa Yang
Jun 20, 2014·Cellular and Molecular Life Sciences : CMLS·Giovanna M ColluKeith Brennan
Oct 13, 2014·Molecular Cancer·Birgit Schittek, Tobias Sinnberg

❮ Previous
Next ❯

Methods Mentioned

BETA
myristoylation

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
S HofvindL A Akslen
International Journal of Clinical and Experimental Pathology
Xiaoyan WangTiefeng Jin
© 2021 Meta ULC. All rights reserved