High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function.

Antimicrobial Agents and Chemotherapy
F LamothO Marchetti

Abstract

High-dose cefepime therapy is recommended for febrile neutropenia. Safety issues have been raised in a recent meta-analysis reporting an increased risk of mortality during cefepime therapy. Cefepime-related neurological toxicity has been associated with overdosing due to severe renal dysfunction. This study aimed to investigate the association between cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients. Cefepime trough concentrations (by high-performance liquid chromatography) were retrospectively analyzed for 30 adult febrile neutropenic patients receiving the recommended high-dose regimen (6 g/day for a glomerular filtration rate [GFR] of >50 ml/min). The dose adjustment to renal function was evaluated by the ratio of the cefepime daily dose per 100 ml/min of glomerular filtration. The association between cefepime plasma concentrations and neurological toxicity was assessed on the basis of consistent neurological symptoms and/or signs (by NCI criteria). The median cefepime concentration was 8.7 mg/liter (range, 2.1 to 38 mg/liter) at a median of 4 days (range, 2 to 15 days) after the start of therapy. Neurological toxicity (altered mental status, hallucinations, or myoclonia) was attribute...Continue Reading

References

Mar 1, 1992·Antimicrobial Agents and Chemotherapy·R H BarbhaiyaR R Martin
Sep 1, 1990·Clinical Pharmacology and Therapeutics·R H BarbhaiyaK A Pittman
Jun 24, 1996·The American Journal of Medicine·H C Neu
Feb 24, 2001·Neurophysiologie clinique = Clinical neurophysiology·P JallonF Assal
Aug 11, 2001·The American Journal of Medicine·J E Martínez-RodríguezC R dela Rosa
Dec 4, 2001·Annals of Internal Medicine·F BarbeyJ P Wauters
Feb 19, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Walter T HughesLowell S Young
Oct 18, 2002·Antimicrobial Agents and Chemotherapy·Denis BugnonPhilippe Moreillon
Mar 12, 2003·Pharmacotherapy·Kai Ming ChowPhilip Kam-Tao Li
May 23, 2003·Antimicrobial Agents and Chemotherapy·Vincent H TamMichael J Rybak
Feb 26, 2004·The Annals of Pharmacotherapy·Sergio AbanadesMagí Farré
Apr 24, 2007·The Lancet Infectious Diseases·Dafna YahavLeonard Leibovici
Jan 8, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J SonckD Verbeelen
Oct 17, 2008·The Lancet Infectious Diseases·Olivier LortholaryUNKNOWN Club de Reflexion sur les Infections en Onco-Hématologie
Feb 21, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thao D NguyenElizabeth Trang

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Citations

Jun 5, 2013·International Journal of Clinical Pharmacy·Akihiro TanakaHiroaki Araki
Feb 3, 2012·The Journal of Antimicrobial Chemotherapy·Charlotte Durand-MaugardMichel Andréjak
Mar 14, 2013·Shock·Rodrigo Spineli MacedoGuilherme Henrique Campos Furtado
Apr 3, 2010·Critical Care : the Official Journal of the Critical Care Forum·Thomas M ChapuisPhilippe Moreillon
Jan 21, 2014·The Journal of Antimicrobial Chemotherapy·Gloria WongJason A Roberts
Feb 11, 2014·Scandinavian Journal of Infectious Diseases·Tomotaka UgaiKosei Matsue
Dec 30, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Nathaniel J RhodesMarc H Scheetz
Feb 19, 2016·Neurology·Shamik BhattacharyyaAaron L Berkowitz
Jun 16, 2012·Internal Medicine Journal·A McNallyD Jardine
Jul 17, 2013·Journal of Separation Science·Regula TheurillatWolfgang Thormann
Nov 7, 2012·Pediatric Neurology·Lindsay C LandgraveChristopher E Belcher
Jan 23, 2013·Journal of Critical Care·Joao Goncalves-Pereira, José-Artur Paiva
Jul 22, 2014·Future Microbiology·Esther BettiolUNKNOWN COMBACTE consortium
May 6, 2016·Journal of the Pediatric Infectious Diseases Society·Holly LindsayJulienne Brackett
Jun 2, 2016·The Journal of Antimicrobial Chemotherapy·Stijn JonckheerePieter Colin
Oct 27, 2016·Biochemical Pharmacology·Çiğdem Yılmaz, Gülay Özcengiz
Oct 28, 2016·Critical Care : the Official Journal of the Critical Care Forum·Khalil ChaïbiMatthieu Legrand
Dec 3, 2016·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshiko YamashitaSatoshi Yamamoto
Jan 24, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T HuwylerA Huttner
Nov 16, 2017·Critical Care : the Official Journal of the Critical Care Forum·Lauren E PayneGilles L Fraser
Dec 12, 2017·Clinical Case Reports·Monica Guzman-LimonJoyce Samuel
Nov 5, 2016·The Annals of Pharmacotherapy·Yvonne J BurnettKristi A Traugott
Jul 15, 2016·Clinical Microbiology Reviews·Mordechai GrupperDavid P Nicolau
Jul 1, 2015·Antimicrobial Agents and Chemotherapy·Fekade Bruck SimeJason A Roberts
Oct 10, 2018·Current Opinion in Infectious Diseases·Aaron J HeffernanJason A Roberts
Nov 12, 2019·The Journal of Antimicrobial Chemotherapy·Cindy LauJonathan Penm
Apr 23, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Manuela HaiducDerek N Bremmer
Nov 7, 2019·Antimicrobial Agents and Chemotherapy·Stijn JonckheerePieter J Colin
Oct 27, 2017·Open Forum Infectious Diseases·Ayesha A AppaPaul S Pottinger
Jul 1, 2020·Antimicrobial Agents and Chemotherapy·Mohammad H Al-ShaerCharles A Peloquin
Jul 30, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Samuel DeshayesRenaud Verdon
Mar 28, 2019·The Neurohospitalist·Dmitry Tchapyjnikov, Matthew W Luedke

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