High central venous pressure is associated with acute kidney injury and mortality in patients underwent cardiopulmonary bypass surgery

Journal of Critical Care
Yanli YangLiyun Zhao

Abstract

We sought to investigate the relationship between high CVP, AKI, and mortality in patients undergoing cardiac surgery with cardiopulmonary bypass. All patients aged 18 years or older who underwent cardiac surgery with CPB were prospectively reviewed. Patients were excluded when renal artery were involved before and during surgery. Patients were dichotomized into high CVP group(>10 mmHg) and low CVP group(<10 mmHg). All patients were followed by telephone. A total of 1941 patients were included in observed study. In high CVP group, three hundred forty-seven patients (43.32%) developed AKI, while eighty-six (7.543%) in low CVP group(P <0.0001). Furthermore, in every KDIGO stage, patients of AKI in high CVP group were more than those in low CVP group(P <0.0001). The incidence of AKI increased as CVP increased, especially when CVP was higher than 10cmH2O. In a median follow-up time of 9.2 months, Crude mortality is 8.365% in the high CVP group compared to 1.929% in the low CVP group (p<0.0001). In multivariate analysis, CVP remained the independent predictor of survival. High CVP is associated with AKI , and it is independently related to all-cause mortality in patients underwent cardiovascular surgery with cardiopulmonary bypass.

Citations

Apr 16, 2020·World Journal for Pediatric & Congenital Heart Surgery·Billy C WangRichard P Lion
Feb 7, 2021·Nature Reviews. Nephrology·Holger ScholzPontus B Persson
Feb 8, 2021·British Journal of Anaesthesia·Marcos G LopezFrederic T Billings
Mar 24, 2021·Critical Care Clinics·Christina MassothMelanie Meersch
Nov 3, 2021·Pediatric Transplantation·Claudia A AlgazeSeth A Hollander

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