Abstract
Osteoporosis is a severe complication of thalassemia. Sclerostin is a Wnt signaling inhibitor, which is produced by osteocytes and inhibits osteoblast function. Sclerostin is implicated in the pathogenesis of osteoporosis of different etiology. The aim of the study was to evaluate circulating sclerostin in 66 patients (median age 42 years) with thalassemia and osteoporosis who participated in a phase 2, randomized study (zoledronic acid vs. placebo) and the results were compared with those of 30 healthy controls (median age 44 years) without osteopenia/osteoporosis and 62 women with postmenopausal osteoporosis (median age 63 years). At baseline, thalassemic patients with osteoporosis had elevated circulating levels of sclerostin (median: 605 pg/ml, range: 22-1,227 pg/ml) compared to healthy controls without osteopenia/osteoporosis (250 pg/ml, 0-720 pg/ml, p<0.001) and reduced levels of sclerostin compared with postmenopausal women with osteoporosis (840 pg/ml, 181-1,704 pg/ml, p<0.001). Thalassemia patients had also increased serum dickkopf-1 (Dkk-1) and high bone turnover. Circulating sclerostin levels correlated with bone mineral density in lumbar spine (r=0.619, p<0.001), distal radius (r=0.401, p=0.001) and femoral neck (r=...Continue Reading
Citations
Sep 4, 2012·Current Hematologic Malignancy Reports·Evangelos TerposMeletios A Dimopoulos
Jan 9, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·E González-ReimersF Santolaria-Fernández
Feb 25, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A G CostaJ P Bilezikian
Apr 22, 2014·Journal of Bone and Mineral Metabolism·Andrea Giusti
Nov 30, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Gregory R Emkey, Sol Epstein
Oct 16, 2015·Expert Review of Hematology·Raffaella OrigaCaterina Borgna-Pignatti
Jan 18, 2014·Expert Review of Hematology·Evangelos TerposG David Roodman
Jul 16, 2015·Transfusion·Symeon TournisNikolaos Papaioannou
Jul 25, 2015·Journal of Bone and Mineral Metabolism·Nunziata MorabitoAntonino Lasco
Jun 10, 2015·Journal of Bone and Mineral Metabolism·Stergios A PolyzosEvangelos Terpos
Aug 10, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A D DedeS Tournis
Feb 28, 2018·The Journal of Physiological Sciences : JPS·Kornkamon LertsuwanNarattaphol Charoenphandhu
May 2, 2019·Annals of Hematology·Ersi VoskaridouEvangelos Terpos
Nov 2, 2018·Blood Advances·Ersi VoskaridouEvangelos Terpos
May 21, 2020·International Journal of Molecular Sciences·Agostino GaudioPietro Castellino
Sep 5, 2013·The Journal of Clinical Endocrinology and Metabolism·Sonsoles BotellaNerea Varo
Sep 16, 2020·Archives of Osteoporosis·Pokpong PiriyakhuntornNipon Chattipakorn
Oct 22, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Mahalakshmi HonasogeSudhaker D Rao
Jan 23, 2019·Hematology·Ersi VoskaridouEvangelos Terpos
Feb 8, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Bushra ParveenDivya Vohora
May 10, 2020·Scientific Reports·Sutada LotinunNateetip Krishnamra
Mar 28, 2020·Annals of Medicine·Katya SapunarovaZhanet Grudeva-Popova
Mar 15, 2019·Current Molecular Medicine·Athanasios N TsartsalisAntonis Kattamis
Oct 3, 2014·The Journal of Bone and Joint Surgery. American Volume·Jocelyn T Compton, Francis Y Lee