High CO2/H+ dialysis in the caudal ventrolateral medulla (Loeschcke's area) increases ventilation in wakefulness.

Respiratory Physiology & Neurobiology
Glauber S F da SilvaEugene Nattie

Abstract

Central chemoreception, the detection of CO(2)/H(+) within the brain and the resultant effect on ventilation, was initially localized at two areas on the ventrolateral medulla, one rostral (rVLM-Mitchell's) the other caudal (cVLM-Loeschcke's), by surface application of acidic solutions in anesthetized animals. Focal dialysis of a high CO(2)/H(+) artificial cerebrospinal fluid (aCSF) that produced a milder local pH change in unanesthetized rats (like that with a approximately 6.6mm Hg increase in arterial P(CO2)) delineated putative chemoreceptor regions for the rVLM at the retrotrapezoid nucleus and the rostral medullary raphe that function predominantly in wakefulness and sleep, respectively. Here we ask if chemoreception in the cVLM can be detected by mild focal stimulation and if it functions in a state dependent manner. At responsive sites just beneath Loeschcke's area, ventilation was increased by, on average, 17% (P<0.01) only in wakefulness. These data support our hypothesis that central chemoreception is a distributed property with some sites functioning in a state dependent manner.

References

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Citations

Nov 13, 2010·Journal of Applied Physiology·Eugene Nattie
Apr 24, 2013·Respiratory Physiology & Neurobiology·Patrice G Guyenet, Stephen B G Abbott
Feb 23, 2010·Respiratory Physiology & Neurobiology·Tomoyuki KuwakiEugene Nattie
Aug 5, 2017·The Journal of Physiology·Isabela P LeirãoGlauber S F da Silva
Sep 23, 2018·Experimental Physiology·Eliandra N da SilvaMirela B Dias
Aug 26, 2010·The Journal of Comparative Neurology·Patrice G GuyenetDouglas A Bayliss
May 20, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Katherine A WilkinsonFrank L Powell
Sep 12, 2020·Pflügers Archiv : European journal of physiology·Isabela P LeirãoGlauber S F da Silva
Nov 22, 2018·Frontiers in Neuroscience·Nicole K Leibold, Koen R Schruers

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