Abstract
Type 2 diabetes mellitus (T2DM) has been considered to be a risk factor for numerous human cancers. Hyperglycemia is one of the most direct internal environmental changes for patients with T2DM. Increasing evidence reveals that a high concentration of glucose can promote tumor progression, while its role for migration and invasion of invasive ductal breast carcinoma (IDBC) cells remains unclear. In the present study, it was demonstrated that IDBC patients with T2DM suffered an increased tumor size and more frequent lymphatic and distant metastasis compared with those without T2DM (P<0.05). MCF-7 breast carcinoma cells, which were cultured in a high glucose concentration medium (25.00 mM), exhibited increased invasion (P<0.05). In addition, the expression of glucose transporters (Gluts), matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) in IDBC tissues with T2DM was significantly higher compared to those without T2DM. Downregulation of glucose transporter 1 (Glut1) by small interfering RNA may markedly suppress MCF-7 cell invasion as well as the expression of MMP2 and MMP9. These results suggest that T2DM can affect the malignant features of tumors in IDBC. The high glucose concentration in the tumor microe...Continue Reading
References
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Sep 7, 2004·Surgery·Hiromichi ItoEdward E Whang
Jul 28, 2012·Archives of Medical Research·Ying-Ying XuJun Fan
Jan 25, 2013·World Journal of Gastroenterology : WJG·Takanori HosokawaNamiki Izumi
Jul 3, 2013·American Journal of Nephrology·Charles W HeiligN Stanley Nahman
Sep 10, 2013·Cell Cycle·Weiwei Yang, Zhimin Lu
Jan 15, 2014·Journal of Molecular Endocrinology·Brett McKinnonMichael D Mueller
May 27, 2014·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Sekhar PalAmitava Chatterjee
May 27, 2014·Molecular Medicine Reports·Junli ZhangQingguang Liu
Aug 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Shu-Ping NieMing Lu
Sep 23, 2014·International Journal of Cancer. Journal International Du Cancer·Hongmei ZengXue Qin Yu
Oct 8, 2014·Oncology Letters·Qiuran XuQingguang Liu
Oct 28, 2014·Advances in Clinical Chemistry·Roland Govers
Nov 18, 2014·PloS One·Sirin A I AdhamBrenda L Coomber
Dec 5, 2014·OncoTargets and Therapy·Fang-Jing MaZhi-Ming Shao
Jan 6, 2015·BMJ : British Medical Journal·Wei-Chih LiaoKuo-Liong Chien
Jan 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Gulzade OzyalvacliFahri Yilmaz
Jan 15, 2015·BioMed Research International·Zhen ChenRutao Cui
Jan 22, 2015·International Journal of Cancer. Journal International Du Cancer·Xiangdong LiuJianguang Ji
Apr 4, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jun OsugiMitsukazu Gotoh
Apr 14, 2015·BioMed Research International·Kyong Hye JoungBon Jeong Ku
Jul 3, 2015·Oncology Letters·Stefan JanssenGabriela Studer
Jun 23, 2016·PloS One·Zheng TangJinming Yu
Dec 5, 2016·Cytokine·Zachary A P WintrobAlice C Ceacareanu
Citations
May 9, 2018·Cancer Science·Jing WuTong Li
Apr 17, 2019·Journal of Neuropathology and Experimental Neurology·Satoru KomakiMotohiro Morioka
Dec 22, 2017·Oncotarget·Huan TuoYi Xuan Yang
Jan 25, 2019·Oncology Letters·Xingkai LiuHaixia Hu
Jul 25, 2019·Journal of Experimental & Clinical Cancer Research : CR·Wenjie LiHong Zhu
Aug 15, 2020·Frontiers in Oncology·Edoardo D'AngeloFederica Collino
Mar 24, 2018·Molecular Medicine Reports·Hangbin JinShenglin Ma
Oct 17, 2020·Surgical Oncology·Xin HuTong Su
Oct 17, 2020·Cancer Management and Research·Jun LuYikai Chen
Feb 25, 2021·FEBS Letters·Rohith Kumar GuddetiSuresh B Pakala
May 27, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Suangson SupabpholCharupong Saengboonmee
May 31, 2021·Cancer Letters·Heba Allah M AlsheikhLalita A Shevde
Jun 17, 2021·Bioengineered·Zhongjian PuHaiqing Hua
Jul 3, 2021·International Journal of Molecular Sciences·Alina D NikotinaIrina V Guzhova