High-concentration glucose enhances invasion in invasive ductal breast carcinoma by promoting Glut1/MMP2/MMP9 axis expression

Oncology Letters
Xian-Fu SunHui Liu

Abstract

Type 2 diabetes mellitus (T2DM) has been considered to be a risk factor for numerous human cancers. Hyperglycemia is one of the most direct internal environmental changes for patients with T2DM. Increasing evidence reveals that a high concentration of glucose can promote tumor progression, while its role for migration and invasion of invasive ductal breast carcinoma (IDBC) cells remains unclear. In the present study, it was demonstrated that IDBC patients with T2DM suffered an increased tumor size and more frequent lymphatic and distant metastasis compared with those without T2DM (P<0.05). MCF-7 breast carcinoma cells, which were cultured in a high glucose concentration medium (25.00 mM), exhibited increased invasion (P<0.05). In addition, the expression of glucose transporters (Gluts), matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) in IDBC tissues with T2DM was significantly higher compared to those without T2DM. Downregulation of glucose transporter 1 (Glut1) by small interfering RNA may markedly suppress MCF-7 cell invasion as well as the expression of MMP2 and MMP9. These results suggest that T2DM can affect the malignant features of tumors in IDBC. The high glucose concentration in the tumor microe...Continue Reading

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Citations

Apr 17, 2019·Journal of Neuropathology and Experimental Neurology·Satoru KomakiMotohiro Morioka
Jul 25, 2019·Journal of Experimental & Clinical Cancer Research : CR·Wenjie LiHong Zhu
May 27, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Suangson SupabpholCharupong Saengboonmee
Jul 3, 2021·International Journal of Molecular Sciences·Alina D NikotinaIrina V Guzhova

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Methods Mentioned

BETA
transfection
electrophoresis
antisense oligodeoxynucleotide

Software Mentioned

SPSS
ImageJ

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