High concentration of ampicillin and the Eagle effect among gram-negative rods

Chemotherapy
K Goldstein, V T Rosdahl

Abstract

79 Escherichia coli strains were investigated by the triple layer technique for the presence of the 'paradoxical zone phenomenon' around an ampicillin disc. 76 strains were positive, 3 negative. 7 positive and 3 negative strains were treated with varying concentrations of ampicillin and counted. Only 5 of the 7 positive strains showed the Eagle effect, all 3 negative strains gave no Eagle effect. The magnitude of the Eagle effect observed is regarded as being of no clinical importance in the treatment of E. coli with high dosages of ampicillin.

Citations

Jan 1, 1991·Urological Research·T GotoY Ohi
Sep 25, 2003·Antimicrobial Agents and Chemotherapy·Luis Ostrosky-ZeichnerJeannette Lee
Sep 24, 2013·Applied and Environmental Microbiology·Gitte M KnudsenLone Gram
Apr 3, 2020·The Pediatric Infectious Disease Journal·Jessica E EricsonUNKNOWN Best Pharmaceuticals for Children Act – Pediatric Trials Network
Jan 1, 1989·Scandinavian Journal of Infectious Diseases. Supplementum·I Odenholt-Tornqvist

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