High concentration versus incremental induction of anesthesia with sevoflurane in children: a comparison of induction times, vital signs, and complications

Journal of Clinical Anesthesia
R H EpsteinJ B Lessin

Abstract

To compare sevoflurane induction times and complications in children during a high concentration, primed-circuit method and an incremental induction technique. Randomized, prospective open-label study. Academic university hospital. 40 unpremedicated ASA physical status I and II children age 4 months to 15 years undergoing elective surgical procedures with general anesthesia. Patients were randomized to one of two study groups. In the high concentration group, the anesthesia circuit was primed with 8% sevoflurane in a 2:1 nitrous oxide:oxygen (N2O:O2) mixture. Patients breathed this gas mixture spontaneously until loss of the eyelash reflex. In the incremental group, the face mask was applied and 1% sevoflurane in a 2:1 N2O:O2 mixture was administered. In this group, the sevoflurane concentration was increased by 1% every 2 to 3 breaths. Gas flows of 6 L/min were administered to both groups during the study period. Following loss of the eyelash reflex, the sevoflurane concentration was decreased to 5% until a depth of anesthesia sufficient to start an intravenous catheter was achieved. Induction cooperation, induction time (face mask application to loss of the eyelash reflex), one-minute vital signs [blood pressure, heart rate, ...Continue Reading

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References

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Citations

Mar 21, 2008·Veterinary Research Communications·L S Barter, J F Antognini
Jun 28, 2000·Journal of Clinical Anesthesia·Y MorimotoM H Zornow
Jun 2, 2011·American Journal of Veterinary Research·Tamas D Ambrisko, Alan M Klide
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Jul 1, 2011·Korean journal of anesthesiology·Josef Holzki
Apr 16, 2009·European Journal of Anaesthesiology·Fengjiang ZhangMin Yan
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Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Matthias L RiessDavid F Stowe
Sep 3, 2019·Frontiers in Pediatrics·Stefania SgròSergio Picardo

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